Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study - PubMed (original) (raw)

Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study

Judith E Carroll et al. Biol Psychiatry. 2017.

Abstract

Background: Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality.

Methods: We examined the association of epigenetic age and immune cell aging with sleep in the Women's Health Initiative study (N = 2078; mean 64.5 ± 7.1 years of age) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short sleep 5 hours or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28-CD45RA-).

Results: Insomnia symptoms were related to advanced epigenetic age (β ± SE = 1.02 ± 0.37, p = .005) after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (β ± SE = 0.59 ± 0.21, p = .006), but not with naive T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late differentiated T cells.

Conclusions: Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naive T cells. In this large population-based study of women in the United States, insomnia symptoms are implicated in accelerated aging.

Keywords: Aging; Epigenetic; Immunosenescence; Insomnia; Methylation; Sleep.

PubMed Disclaimer

Conflict of interest statement

FINANCIAL DISCLOSURES

All authors report no biomedical financial interests or potential conflicts of interest.

Figures

Figure 1

Mean difference in extrinsic epigenetic age acceleration by number of insomnia symptoms.

Cited by

Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging.
Win PW, Nyugen J, Morin AL, Newcomb CE, Singh SM, Gomaa N, Castellani CA. Win PW, et al. BMC Res Notes. 2024 Jan 11;17(1):21. doi: 10.1186/s13104-023-06673-9. BMC Res Notes. 2024. PMID: 38212867 Free PMC article.
Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology.
Roth-Walter F, Adcock IM, Benito-Villalvilla C, Bianchini R, Bjermer L, Caramori G, Cari L, Chung KF, Diamant Z, Eguiluz-Gracia I, Knol EF, Jesenak M, Levi-Schaffer F, Nocentini G, O'Mahony L, Palomares O, Redegeld F, Sokolowska M, Van Esch BCAM, Stellato C. Roth-Walter F, et al. Allergy. 2024 May;79(5):1089-1122. doi: 10.1111/all.15977. Epub 2023 Dec 18. Allergy. 2024. PMID: 38108546 Free PMC article. Review.
Air pollution, particulate matter composition and methylation-based biologic age.
White AJ, Kresovich JK, Keller JP, Xu Z, Kaufman JD, Weinberg CR, Taylor JA, Sandler DP. White AJ, et al. Environ Int. 2019 Nov;132:105071. doi: 10.1016/j.envint.2019.105071. Epub 2019 Aug 3. Environ Int. 2019. PMID: 31387022 Free PMC article.
Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT.
Matsuyama M, WuWong DJ, Horvath S, Matsuyama S. Matsuyama M, et al. Aging (Albany NY). 2019 May 21;11(10):3012-3022. doi: 10.18632/aging.101955. Aging (Albany NY). 2019. PMID: 31113906 Free PMC article.
Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study.
Mandelblatt JS, Zhou X, Small BJ, Ahn J, Zhai W, Ahles T, Extermann M, Graham D, Jacobsen PB, Jim H, McDonald BC, Patel SJ, Root JC, Saykin AJ, Cohen HJ, Carroll JE. Mandelblatt JS, et al. J Natl Cancer Inst. 2021 Aug 2;113(8):1053-1064. doi: 10.1093/jnci/djab003. J Natl Cancer Inst. 2021. PMID: 33484565 Free PMC article.

References

1. Irwin MR, Olmstead R, Carroll JE. Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry. 2015 doi: 10.1016/j.biopsych.2015.05.014. - DOI - PMC - PubMed
1. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6:97–111. - PubMed
1. Center for Disease Control. CDC Data & Statistics | Feature: Insufficient Sleep Is a Public Health Epidemic. 2011 Retrieved August 4, 2011, from http://www.cdc.gov/Features/dsSleep/
1. Colten HR, Altevogt BM. Sleep disorders and sleep deprivation: an unmet public health problem. National Academies Press; 2006. - PubMed
1. Motivala SJ. Sleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease. Ann Behav Med. 2011;42:141–152. - PubMed

Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study - PubMed (original) (raw)