Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes - PubMed (original) (raw)

Figure 6 |. Virulence and resistance profiles across the phylogeny of the 1,696 Lm isolates.

a, Cluster analysis based on cgMLST profiles. The dashed vertical bar indicates the cgMLST mismatch cutoff for sublineages. The ten most frequent sublineages are highlighted. b, Pattern of gene presence (colour line) or absence (white). The first and last columns correspond to the serogroup and sample source, respectively, represented by colour codes (upper left key). The presence/absence gene matrix represents, from left to right, genes involved in teichoic acid biosynthesis (gltAB, tagB, gtcA), genes located in the pathogenicity islands LIPI-1 (prfA, plcA, hly, mpl, actA, plcB), LIPI-3 (llsAGHXBYDP) and LIPI-4 (LM9005581_70009 to LM9005581_70014), genes coding for internalins (inlABCEFGHJK) and other genes involved in adherence (ami, dltA, fbpA, lap, lapB), invasion (aut, aut_IVb, cwhA, lpeA, vip), intracellular survival (hpt, lplA1, oppA, prsA2, purQ, svpA), regulation of transcription and translation (agrAC, cheAY, fur, lisKR, rsbV, sigB, stp, virRS), surface protein anchoring (lgt, lspA, srtAB), peptidoglycan modification (oatA, pdgA), immune modulation (lntA), bile-resistance (bsh, mdrM, mdrT, brtA), resistance to detergents (qac, bcrABC, ermE) and biofilm formation and virulence (comK).