Gene Regulation: Activation through Space - PubMed (original) (raw)

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. 2016 Oct 10;26(19):R895-R898.

doi: 10.1016/j.cub.2016.08.031. Epub 2016 Oct 10.

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• PMID: 27728794
• DOI: 10.1016/j.cub.2016.08.031

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Gene Regulation: Activation through Space

Felix Muerdter et al. Curr Biol. 2016.

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Abstract

A recent study visualizes nascent RNAs in live Drosophila embryos to establish a connection between enhancer strength and the frequency of transcriptional bursts. Interestingly, one enhancer can simultaneously activate two core promoters, challenging models of enhancer-core-promoter communication via direct protein-protein contacts.

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• Enhancer Control of Transcriptional Bursting.
  Fukaya T, Lim B, Levine M. Fukaya T, et al. Cell. 2016 Jul 14;166(2):358-368. doi: 10.1016/j.cell.2016.05.025. Epub 2016 Jun 9. Cell. 2016. PMID: 27293191 Free PMC article.
• A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting.
  Tantale K, Mueller F, Kozulic-Pirher A, Lesne A, Victor JM, Robert MC, Capozi S, Chouaib R, Bäcker V, Mateos-Langerak J, Darzacq X, Zimmer C, Basyuk E, Bertrand E. Tantale K, et al. Nat Commun. 2016 Jul 27;7:12248. doi: 10.1038/ncomms12248. Nat Commun. 2016. PMID: 27461529 Free PMC article.

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