Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus - PubMed (original) (raw)
Comparative Study
Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus
T M Chambers et al. Virology. 1989 Sep.
Abstract
Influenza A viruses with subtype H13 hemagglutinin display an unusual host range. Although common in shorebirds, they are very rare or absent in wild ducks; additionally, H13 viruses have been isolated from a whale. To study the molecular basis for this host range, we have determined the complete nucleotide sequences of the hemagglutinin genes of three H13 influenza viruses from different species or geographical areas: A/gull/Maryland/77, A/gull/Astrachan (USSR)/84, and A/pilot whale/Maine/84. Based on the deduced amino acid sequences, H13 hemagglutinin shares the basic structure of other type A hemagglutinin subtypes such as H3, but has clearly diverged from other completely sequenced subtypes. Unique features of H13 hemagglutinin include the occurrence, near the receptor binding pocket, of residues Arg/Lys-227 and Trp-229 (H3 numbering); the significance of these are unknown. The sequence of the HA1-HA2 cleavage site resembles those of avirulent avian influenza viruses. The whale H13 hemagglutinin is similar to those from gulls, supporting the hypothesis that influenza viruses from avian sources can enter marine mammal populations but are probably not permanently maintained there. Antigenic analysis using a panel of monoclonal antibodies suggests that, like other subtypes, H13 viruses are heterogeneous, with different antigenic variants predominating in the eastern versus the western hemispheres.
Similar articles
- Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls.
Verhagen JH, Höfle U, van Amerongen G, van de Bildt M, Majoor F, Fouchier RA, Kuiken T. Verhagen JH, et al. J Virol. 2015 Nov;89(22):11507-22. doi: 10.1128/JVI.01765-15. Epub 2015 Sep 2. J Virol. 2015. PMID: 26339062 Free PMC article. - Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls.
Hinshaw VS, Air GM, Gibbs AJ, Graves L, Prescott B, Karunakaran D. Hinshaw VS, et al. J Virol. 1982 Jun;42(3):865-72. doi: 10.1128/JVI.42.3.865-872.1982. J Virol. 1982. PMID: 7097861 Free PMC article. - Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls.
Fouchier RA, Munster V, Wallensten A, Bestebroer TM, Herfst S, Smith D, Rimmelzwaan GF, Olsen B, Osterhaus AD. Fouchier RA, et al. J Virol. 2005 Mar;79(5):2814-22. doi: 10.1128/JVI.79.5.2814-2822.2005. J Virol. 2005. PMID: 15709000 Free PMC article. - Structure of the influenza virus hemagglutinin.
Ward CW. Ward CW. Curr Top Microbiol Immunol. 1981;94-95:1-74. doi: 10.1007/978-3-642-68120-2_1. Curr Top Microbiol Immunol. 1981. PMID: 6171388 Review. No abstract available. - Influenza A viruses: combinations of hemagglutinin and neuraminidase subtypes isolated from animals and other sources.
Hinshaw VS, Webster RG, Rodriguez RJ. Hinshaw VS, et al. Arch Virol. 1981;67(3):191-201. doi: 10.1007/BF01318130. Arch Virol. 1981. PMID: 6164356 Review. No abstract available.
Cited by
- Evolution and ecology of influenza A viruses.
Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Webster RG, et al. Microbiol Rev. 1992 Mar;56(1):152-79. doi: 10.1128/mr.56.1.152-179.1992. Microbiol Rev. 1992. PMID: 1579108 Free PMC article. Review. - Pandemic threat posed by avian influenza A viruses.
Horimoto T, Kawaoka Y. Horimoto T, et al. Clin Microbiol Rev. 2001 Jan;14(1):129-49. doi: 10.1128/CMR.14.1.129-149.2001. Clin Microbiol Rev. 2001. PMID: 11148006 Free PMC article. Review. - Genetic and antigenic analysis of an equine influenza H 3 isolate from the 1989 epidemic.
Binns MM, Daly JM, Chirnside ED, Mumford JA, Wood JM, Richards CM, Daniels RS. Binns MM, et al. Arch Virol. 1993;130(1-2):33-43. doi: 10.1007/BF01318994. Arch Virol. 1993. PMID: 8503788 - Molecular characterization and phylogenetics of a reassortant H13N8 influenza virus isolated from gulls in Mongolia.
Sharshov K, Sivay M, Liu D, Pantin-Jackwood M, Marchenko V, Durymanov A, Alekseev A, Damdindorj T, Gao GF, Swayne DE, Shestopalov A. Sharshov K, et al. Virus Genes. 2014 Oct;49(2):237-49. doi: 10.1007/s11262-014-1083-7. Epub 2014 May 18. Virus Genes. 2014. PMID: 24839173 - A rice protein library: a data-file of rice proteins separated by two-dimensional electrophoresis.
Komatsu S, Kajiwara H, Hirano H. Komatsu S, et al. Theor Appl Genet. 1993 Sep;86(8):935-42. doi: 10.1007/BF00211044. Theor Appl Genet. 1993. PMID: 24194000
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous