Immunogenic cell death in cancer and infectious disease - PubMed (original) (raw)
Review
doi: 10.1038/nri.2016.107. Epub 2016 Oct 17.
Affiliations
- PMID: 27748397
- DOI: 10.1038/nri.2016.107
Review
Immunogenic cell death in cancer and infectious disease
Lorenzo Galluzzi et al. Nat Rev Immunol. 2017 Feb.
Abstract
Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death. Several infectious pathogens have devised strategies to control cell death and limit the emission of danger signals from dying cells, thereby avoiding immune recognition. Similarly, cancer cells often escape immunosurveillance owing to defects in the molecular machinery that underlies the release of endogenous adjuvants. Here, we review current knowledge on the mechanisms that underlie the activation of immune responses against dying cells and their pathophysiological relevance.
Comment in
- The complement system is also important in immunogenic cell death.
Jin J, He S. Jin J, et al. Nat Rev Immunol. 2017 Feb;17(2):143. doi: 10.1038/nri.2016.142. Epub 2016 Dec 28. Nat Rev Immunol. 2017. PMID: 28028311 No abstract available. - Reply: The complement system is also important in immunogenic cell death.
Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Galluzzi L, et al. Nat Rev Immunol. 2017 Feb;17(2):143. doi: 10.1038/nri.2016.143. Epub 2016 Dec 28. Nat Rev Immunol. 2017. PMID: 28028312 No abstract available. - Reply: Immunosuppressive cell death in cancer.
Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Galluzzi L, et al. Nat Rev Immunol. 2017 Jun;17(6):402. doi: 10.1038/nri.2017.48. Epub 2017 May 8. Nat Rev Immunol. 2017. PMID: 28480896 No abstract available. - Immunosuppressive cell death in cancer.
Hou J, Greten TF, Xia Q. Hou J, et al. Nat Rev Immunol. 2017 Jun;17(6):401. doi: 10.1038/nri.2017.46. Epub 2017 May 8. Nat Rev Immunol. 2017. PMID: 28480899 Free PMC article. No abstract available.
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