Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit - PubMed (original) (raw)

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Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit

Luke Y Prince et al. Front Synaptic Neurosci. 2016.

Abstract

The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

Keywords: CA3; acetylcholine; computational modeling; dentate gyrus; dopamine; mossy fiber; noradrenaline; serotonin.

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Figures

Figure 1

Circuit schemas for DG-CA3 microcicuit. (A) Detailed schematic showing approximate locations of synaptic connections to CA3 pyramidal cells and differences in axon terminals. (B) Simplified schematic showing feedforward and recurrent circuits with feedforward and feedback inhibition.

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