A highly accurate method of localizing regions of neuronal activation in the human brain with positron emission tomography - PubMed (original) (raw)

A highly accurate method of localizing regions of neuronal activation in the human brain with positron emission tomography

M A Mintun et al. J Cereb Blood Flow Metab. 1989 Feb.

Abstract

Functional mapping of the human brain with positron emission tomography (PET) can best be performed by obtaining multiple short measurements of cerebral blood flow in a single sitting. In this manner regional changes in blood flow accompanying the increased neuronal activity from a movement, sensation, or even cognition task, have been identified. However, localizing a functional region with PET has been severely limited by the poor resolving properties of PET devices. Using a new method of data analysis we recently reported the mapping of visual field stimuli on human visual cortex with surprisingly high reliability as measured by the low standard deviation in positions across different subjects (as low as 1 mm). In this work the analysis technique enabling such high-resolution functional brain mapping is fully described. Additionally, simulations are presented to illustrate its advantages and limitations.

PubMed Disclaimer

Similar articles

• [Integrated and automated data analysis for neuronal activation studies using positron emission tomography: methodology and applications].
  Minoshima S, Koeppe RA, Kuhl DE, Arimizu N. Minoshima S, et al. Kaku Igaku. 1994 Aug;31(8):891-908. Kaku Igaku. 1994. PMID: 7933678 Clinical Trial. Japanese.
• Using (10)CO2 for single subject characterization of the stimulus frequency dependence in visual cortex: a novel positron emission tomography tracer for human brain mapping.
  Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Law I, et al. J Cereb Blood Flow Metab. 2001 Aug;21(8):1003-12. doi: 10.1097/00004647-200108000-00013. J Cereb Blood Flow Metab. 2001. PMID: 11487736
• Effects of timing and duration of cognitive activation in [15O]water PET studies.
  Hurtig RR, Hichwa RD, O'Leary DS, Boles Ponto LL, Narayana S, Watkins GL, Andreasen NC. Hurtig RR, et al. J Cereb Blood Flow Metab. 1994 May;14(3):423-30. doi: 10.1038/jcbfm.1994.53. J Cereb Blood Flow Metab. 1994. PMID: 8163584
• Predicting human functional maps with neural net modeling.
  Horwitz B, Tagamets MA. Horwitz B, et al. Hum Brain Mapp. 1999;8(2-3):137-42. doi: 10.1002/(sici)1097-0193(1999)8:2/3<137::aid-hbm11>3.0.co;2-b. Hum Brain Mapp. 1999. PMID: 10524605 Free PMC article. Review.
• Quantitative positron emission tomography and single photon emission computed tomography measurements of human cerebral blood flow.
  Lagrèze HL, Levine RL. Lagrèze HL, et al. Am J Physiol Imaging. 1987;2(4):208-15. Am J Physiol Imaging. 1987. PMID: 3330454 Review.

Cited by

• Neural correlates of emotional reactivity in sensation seeking.
  Joseph JE, Liu X, Jiang Y, Lynam D, Kelly TH. Joseph JE, et al. Psychol Sci. 2009 Feb;20(2):215-23. doi: 10.1111/j.1467-9280.2009.02283.x. Psychol Sci. 2009. PMID: 19222814 Free PMC article.
• Cognition-activated low-frequency modulation of light absorption in human brain.
  Chance B, Zhuang Z, UnAh C, Alter C, Lipton L. Chance B, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3770-4. doi: 10.1073/pnas.90.8.3770. Proc Natl Acad Sci U S A. 1993. PMID: 8475128 Free PMC article.
• Evaluation of hemispheric dominance for language using functional MRI: a comparison with positron emission tomography.
  Xiong J, Rao S, Gao JH, Woldorff M, Fox PT. Xiong J, et al. Hum Brain Mapp. 1998;6(1):42-58. doi: 10.1002/(sici)1097-0193(1998)6:1<42::aid-hbm4>3.0.co;2-l. Hum Brain Mapp. 1998. PMID: 9673662 Free PMC article. Clinical Trial.
• Concurrent TMS to the primary motor cortex augments slow motor learning.
  Narayana S, Zhang W, Rogers W, Strickland C, Franklin C, Lancaster JL, Fox PT. Narayana S, et al. Neuroimage. 2014 Jan 15;85 Pt 3(0 3):971-84. doi: 10.1016/j.neuroimage.2013.07.024. Epub 2013 Jul 15. Neuroimage. 2014. PMID: 23867557 Free PMC article. Clinical Trial.
• Functional anatomic studies of memory retrieval for auditory words and visual pictures.
  Buckner RL, Raichle ME, Miezin FM, Petersen SE. Buckner RL, et al. J Neurosci. 1996 Oct 1;16(19):6219-35. doi: 10.1523/JNEUROSCI.16-19-06219.1996. J Neurosci. 1996. PMID: 8815903 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon