Cerebral Mast Cells Participate In Postoperative Cognitive Dysfunction by Promoting Astrocyte Activation - PubMed (original) (raw)
doi: 10.1159/000452528. Epub 2016 Nov 18.
Affiliations
- PMID: 27855371
- DOI: 10.1159/000452528
Free article
Cerebral Mast Cells Participate In Postoperative Cognitive Dysfunction by Promoting Astrocyte Activation
Xiang Zhang et al. Cell Physiol Biochem. 2016.
Free article
Erratum in
- Erratum.
[No authors listed] [No authors listed] Cell Physiol Biochem. 2020;54(4):793. doi: 10.33594/000000257. Cell Physiol Biochem. 2020. PMID: 32853502 No abstract available.
Abstract
Background: Astrocytes, the major glial cell type that has been increasingly recognized as contributing to neuroinflammation, are critical in the occurrence and development of postoperative cognitive dysfunction (POCD). Although emerging evidence showed that brain mast cells (MCs) are the "first responders" in neuroinflammation, little is known about the functional communication between MCs and astrocytes.
Methods: In this study, we investigated the potential regulation of astrocyte activation by MCs. Rats received an intracerebroventricular injection of Cromolyn (an MC stabilizer) or sterile saline 30 min before undergoing open tibial fracture surgery, and the levels of neuroinflammation and the degree of memory dysfunction were evaluated at 1 day and 3 days after surgery. In the in vitro study, the effect of activated MCs on astrocytes were further clarified.
Results: Surgery increased the number of MCs, the astrocyte activation and the production of inflammatory factors, and resulted in cognitive deficits. Site-directed pre-injection of Cromolyn can inhibit this effect. In the vitro study, the conditioned medium from C48/80-stimulated mast cells (P815) could induce primary astrocyte activation and subsequent production of inflammatory cytokines, which could be inhibited by Cromolyn.
Conclusion: These findings indicate that activated MCs could trigger astrocyte activation, be involved in neuroinflammation and possibly contribute to POCD. Interactions between MCs and astrocytes could provide potential therapeutic targets for POCD.
© 2016 The Author(s) Published by S. Karger AG, Basel.
Similar articles
- Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis.
Zhang X, Dong H, Li N, Zhang S, Sun J, Zhang S, Qian Y. Zhang X, et al. J Neuroinflammation. 2016 May 31;13(1):127. doi: 10.1186/s12974-016-0592-9. J Neuroinflammation. 2016. PMID: 27245661 Free PMC article. - Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation.
Xu J, Dong H, Qian Q, Zhang X, Wang Y, Jin W, Qian Y. Xu J, et al. Behav Brain Res. 2017 Aug 14;332:145-153. doi: 10.1016/j.bbr.2017.05.066. Epub 2017 Jun 3. Behav Brain Res. 2017. PMID: 28587818 - Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption.
Zhang S, Dong H, Zhang X, Li N, Sun J, Qian Y. Zhang S, et al. Behav Brain Res. 2016 Feb 1;298(Pt B):158-66. doi: 10.1016/j.bbr.2015.11.003. Epub 2015 Nov 7. Behav Brain Res. 2016. PMID: 26554724 - Bidirectional relationship of mast cells-neurovascular unit communication in neuroinflammation and its involvement in POCD.
Li N, Zhang X, Dong H, Hu Y, Qian Y. Li N, et al. Behav Brain Res. 2017 Mar 30;322(Pt A):60-69. doi: 10.1016/j.bbr.2017.01.006. Epub 2017 Jan 9. Behav Brain Res. 2017. PMID: 28082194 Review. - Unveiling the role of astrocytes in postoperative cognitive dysfunction.
He L, Duan X, Li S, Zhang R, Dai X, Lu M. He L, et al. Ageing Res Rev. 2024 Mar;95:102223. doi: 10.1016/j.arr.2024.102223. Epub 2024 Feb 5. Ageing Res Rev. 2024. PMID: 38325753 Review.
Cited by
- Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders.
Cheng C, Wan H, Cong P, Huang X, Wu T, He M, Zhang Q, Xiong L, Tian L. Cheng C, et al. J Neuroinflammation. 2022 Dec 12;19(1):297. doi: 10.1186/s12974-022-02656-y. J Neuroinflammation. 2022. PMID: 36503642 Free PMC article. Review. - Electroacupuncture Ameliorates Tibial Fracture-Induced Cognitive Dysfunction by Elevating _α_7nAChR Expression and Suppressing Mast Cell Degranulation in the Hippocampus of Rats.
Zhou Y, Hu C, Mao C, Li S, Cui Y, Qian Y. Zhou Y, et al. Evid Based Complement Alternat Med. 2022 Apr 12;2022:3182220. doi: 10.1155/2022/3182220. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35463074 Free PMC article. - Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction.
Liu PR, Cao F, Zhang Y, Peng S. Liu PR, et al. J Int Med Res. 2019 Aug;47(8):3860-3873. doi: 10.1177/0300060519860026. Epub 2019 Jul 16. J Int Med Res. 2019. PMID: 31311378 Free PMC article. - The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure.
Renz-Polster H, Tremblay ME, Bienzle D, Fischer JE. Renz-Polster H, et al. Front Cell Neurosci. 2022 May 9;16:888232. doi: 10.3389/fncel.2022.888232. eCollection 2022. Front Cell Neurosci. 2022. PMID: 35614970 Free PMC article. - Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes.
Xu J, Zhang X, Qian Q, Wang Y, Dong H, Li N, Qian Y, Jin W. Xu J, et al. J Neuroinflammation. 2018 Feb 13;15(1):41. doi: 10.1186/s12974-018-1068-x. J Neuroinflammation. 2018. PMID: 29433511 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical