Noninvasive functional brain mapping by change-distribution analysis of averaged PET images of H215O tissue activity - PubMed (original) (raw)

Affiliations

• PMID: 2786929

Free article

Noninvasive functional brain mapping by change-distribution analysis of averaged PET images of H215O tissue activity

P T Fox et al. J Nucl Med. 1989 Feb.

Free article

Abstract

Change-distribution analysis and intersubject averaging of subtracted positron emission tomography (PET) images are new techniques for detecting, localizing, and quantifying state-dependent focal transients in neuronal activity. We previously described their application to cerebral blood flow images (intravenous bolus H215O, Kety autoradiographic model). We now describe their application to images of H215O regional tissue activity without conversion to units of blood flow. The sensitivity and specificity of response detection and the accuracy of response localization were virtually identical for the two types of images. Response magnitude expressed in percent change from rest was slightly, but consistently smaller in tissue-activity images. Response magnitude expressed in z-score was the same for the two-image types. Most research and clinical applications of functional brain mapping can employ images of H215O tissue activity (intravenous bolus, 40-sec nondynamic scan) without conversion to units of blood flow. This eliminates arterial blood sampling, thereby simplifying and minimizing the invasivity of the PET procedure.

PubMed Disclaimer

Similar articles

• A system for cerebral blood flow measurement using an H215O autoradiographic method and positron emission tomography.
  Kanno I, Iida H, Miura S, Murakami M, Takahashi K, Sasaki H, Inugami A, Shishido F, Uemura K. Kanno I, et al. J Cereb Blood Flow Metab. 1987 Apr;7(2):143-53. doi: 10.1038/jcbfm.1987.37. J Cereb Blood Flow Metab. 1987. PMID: 3558497
• Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
  Raichle ME, Martin WR, Herscovitch P, Mintun MA, Markham J. Raichle ME, et al. J Nucl Med. 1983 Sep;24(9):790-8. J Nucl Med. 1983. PMID: 6604140
• Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans.
  Hattori N, Bergsneider M, Wu HM, Glenn TC, Vespa PM, Hovda DA, Phelps ME, Huang SC. Hattori N, et al. J Nucl Med. 2004 May;45(5):765-70. J Nucl Med. 2004. PMID: 15136624

Cited by

• Statistical limitations in functional neuroimaging. II. Signal detection and statistical inference.
  Petersson KM, Nichols TE, Poline JB, Holmes AP. Petersson KM, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1261-81. doi: 10.1098/rstb.1999.0478. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10466150 Free PMC article. Review.
• A default mode of brain function.
  Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. Raichle ME, et al. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82. doi: 10.1073/pnas.98.2.676. Proc Natl Acad Sci U S A. 2001. PMID: 11209064 Free PMC article.
• Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: a (15)O-H(2)O PET study.
  Monkul ES, Silva LA, Narayana S, Peluso MA, Zamarripa F, Nery FG, Najt P, Li J, Lancaster JL, Fox PT, Lafer B, Soares JC. Monkul ES, et al. Hum Brain Mapp. 2012 Feb;33(2):272-9. doi: 10.1002/hbm.21212. Epub 2011 Mar 9. Hum Brain Mapp. 2012. PMID: 21391267 Free PMC article.
• Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI.
  Narayana S, Parsons MB, Zhang W, Franklin C, Schiller K, Choudhri AF, Fox PT, LeDoux MS, Cannito M. Narayana S, et al. Neuroimage Clin. 2020;27:102285. doi: 10.1016/j.nicl.2020.102285. Epub 2020 Jun 1. Neuroimage Clin. 2020. PMID: 32521476 Free PMC article.
• A 15O-H2O PET study of meditation and the resting state of normal consciousness.
  Lou HC, Kjaer TW, Friberg L, Wildschiodtz G, Holm S, Nowak M. Lou HC, et al. Hum Brain Mapp. 1999;7(2):98-105. doi: 10.1002/(SICI)1097-0193(1999)7:2<98::AID-HBM3>3.0.CO;2-M. Hum Brain Mapp. 1999. PMID: 9950067 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • HighWire