A scavenger peptide prevents methylglyoxal induced pain in mice - PubMed (original) (raw)
. 2017 Mar;1863(3):654-662.
doi: 10.1016/j.bbadis.2016.12.001. Epub 2016 Dec 6.
Thomas Fleming 2, Svenja De Buhr 3, Barbro Beijer 3, Thomas Lindner 3, Artjom Wischnjow 3, Zoltan Kender 4, Verena Peters 5, Stefan Kopf 6, Uwe Haberkorn 3, Walter Mier 3, Peter P Nawroth 7
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- PMID: 27932057
- DOI: 10.1016/j.bbadis.2016.12.001
Free article
A scavenger peptide prevents methylglyoxal induced pain in mice
Sebastian Brings et al. Biochim Biophys Acta Mol Basis Dis. 2017 Mar.
Free article
Abstract
The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG. It was shown to reduce the formation of albumin-MG adducts in vitro and prevented MG-induced pain by reducing plasma MG levels through the formation of peptide-MG adducts in vivo. CycK(Myr)R4E therefore presents a promising option for the treatment of pain and other diabetic complications associated with high MG levels.
Keywords: Diabetic complications; Methylglyoxal; Pain; Peptide; Scavenger.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
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