Genetic identification of familial hypercholesterolemia within a single U.S. health care system - PubMed (original) (raw)
. 2016 Dec 23;354(6319):aaf7000.
doi: 10.1126/science.aaf7000.
Kandamurugu Manickam 2, Laney K Jones 2, Eric A Wright 2, Dustin N Hartzel 2, Claudia Gonzaga-Jauregui 1, Colm O'Dushlaine 1, Joseph B Leader 2, H Lester Kirchner 2, D'Andra M Lindbuchler 2, Marci L Barr 2, Monica A Giovanni 2, Marylyn D Ritchie 2, John D Overton 1, Jeffrey G Reid 1, Raghu P R Metpally 2, Amr H Wardeh 2, Ingrid B Borecki 1, George D Yancopoulos 1, Aris Baras 1, Alan R Shuldiner 1, Omri Gottesman 1, David H Ledbetter 2, David J Carey 2, Frederick E Dewey 1, Michael F Murray 3
Affiliations
- PMID: 28008010
- DOI: 10.1126/science.aaf7000
Genetic identification of familial hypercholesterolemia within a single U.S. health care system
Noura S Abul-Husn et al. Science. 2016.
Abstract
Familial hypercholesterolemia (FH) remains underdiagnosed despite widespread cholesterol screening. Exome sequencing and electronic health record (EHR) data of 50,726 individuals were used to assess the prevalence and clinical impact of FH-associated genomic variants in the Geisinger Health System. The estimated FH prevalence was 1:256 in unselected participants and 1:118 in participants ascertained via the cardiac catheterization laboratory. FH variant carriers had significantly increased risk of coronary artery disease. Only 24% of carriers met EHR-based presequencing criteria for probable or definite FH diagnosis. Active statin use was identified in 58% of carriers; 46% of statin-treated carriers had a low-density lipoprotein cholesterol level below 100 mg/dl. Thus, we find that genomic screening can prompt the diagnosis of FH patients, most of whom are receiving inadequate lipid-lowering therapy.
Copyright © 2016, American Association for the Advancement of Science.
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