Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: A Systematic Review and Meta-Analysis - PubMed (original) (raw)

Review

. 2017 Mar;12(1):194-203.

doi: 10.1007/s11481-016-9722-5. Epub 2016 Dec 26.

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Review

Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Ross Penninkilampi et al. J Neuroimmune Pharmacol. 2017 Mar.

Abstract

Immunotherapeutics targeting amyloid-β (Aβ) have had mixed results in clinical trials. The present study aims to evaluate the safety and clinical efficacy of immunotherapeutic agents targeting Aβ in Alzheimer's disease. Randomised controlled trials of at least two weeks duration were included in the review. Fourteen randomised controlled trials (n = 5554) were identified in a systematic search of eight electronic databases. Upon pooling of data, there was no increased risk of any adverse event, serious adverse events, or death with the exception of a near fivefold increase in amyloid-related imaging abnormalities (ARIA; OR 4.79, 95% CI 1.24-18.55; p = 0.02). Of the cognitive indicators, the Mini-Mental State Examination (MMSE) showed a small statistically significant improvement (diff in means =0.44; p = 0.02), while the others (ADAS-cog, ADCS-ADL, and CDR-sb) showed no change. Therefore, immunotherapeutic agents have been relatively well tolerated, with some promise for cognitive improvements if the occurrence of ARIA can be mitigated.

Keywords: Alzheimer’s disease; Amyloid-β; Immunotherapy; Meta-analysis, ARIA.

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References

    1. Curr Alzheimer Res. 2007 Apr;4(2):191-7 - PubMed
    1. Alzheimers Dement. 2016 Feb;12 (2):110-120 - PubMed
    1. J Neurosci. 2004 Jul 7;24(27):6144-51 - PubMed
    1. Neurobiol Aging. 2013 Nov;34(11):2613-22 - PubMed
    1. Curr Pharm Des. 2008;14(16):1601-5 - PubMed

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