Dual role of histamine on microglia-induced neurodegeneration - PubMed (original) (raw)
Review
. 2017 Mar;1863(3):764-769.
doi: 10.1016/j.bbadis.2016.12.016. Epub 2017 Jan 2.
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- PMID: 28057587
- DOI: 10.1016/j.bbadis.2016.12.016
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Review
Dual role of histamine on microglia-induced neurodegeneration
S Barata-Antunes et al. Biochim Biophys Acta Mol Basis Dis. 2017 Mar.
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Abstract
Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation. Previously, we reported that the administration of histamine induces a deleterious effect by promoting a pro-inflammatory phenotype on microglia that in turn compromises dopaminergic neuronal survival. Contrary, under lipopolysaccharide challenge, histamine inhibits the injurious effect of microglia-mediated inflammation, protecting dopaminergic neurons, suggesting that the modulation of microglial activity is dependent on the environmental context. Thus, histamine and/or histamine receptor agonists may serve to develop new therapeutic approaches to overcome neurodegenerative disorders.
Keywords: Histamine; Lipopolysaccharide; Microglia; Neurodegeneration; Neuroinflammation; Parkinson's disease.
Copyright © 2017 Elsevier B.V. All rights reserved.
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