Gauging circadian variation in ketamine metabolism by real-time breath analysis - PubMed (original) (raw)
. 2017 Feb 14;53(14):2264-2267.
doi: 10.1039/c6cc09061c.
Affiliations
- PMID: 28150005
- DOI: 10.1039/c6cc09061c
Gauging circadian variation in ketamine metabolism by real-time breath analysis
P Martinez-Lozano Sinues et al. Chem Commun (Camb). 2017.
Abstract
The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate the time-dependence of drug metabolism.
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