Modelling gene-environment interaction in first episodes of psychosis - PubMed (original) (raw)
Multicenter Study
doi: 10.1016/j.schres.2017.01.058. Epub 2017 Feb 5.
Miquel Bioque 2, Bibiana Cabrera 2, Antonio Lobo 3, Ana González-Pinto 4, Laura Pina 5, Iluminada Corripio 6, Julio Sanjuán 7, Anna Mané 8, Josefina Castro-Fornieles 9, Eduard Vieta 10, Celso Arango 5, Gisela Mezquida 2, Patricia Gassó 11, Mara Parellada 5, Jerónimo Saiz-Ruiz 12, Manuel J Cuesta 13, Sergi Mas 11; PEPs GROUP
Affiliations
- PMID: 28179063
- DOI: 10.1016/j.schres.2017.01.058
Multicenter Study
Modelling gene-environment interaction in first episodes of psychosis
Miguel Bernardo et al. Schizophr Res. 2017 Nov.
Abstract
Introduction: Recent research demonstrates the heterogeneous etiology of psychotic disorders, where gen-environment (GxE) interaction plays a key role. Large genetic studies have linked many genetic variants with schizophrenia, but each variant is only associated with a small effect and the GxE interaction contribution has not been evaluated.
Methods: The PEPs Project was designed to carefully collect a large amount of genetic and environmental exposure data of 335 FEP patients and 253 matched healthy controls.780single-nucleotide polymorphisms (from 159 candidate genes)and 16 environmental variables previously reported as the main psychosis non-genetic risk factors were analyzed together using entropy-based measures of information gain.
Results: Our analyses identified an interaction between nine SNPs and the exposition to the environmental risk factors of psychosis, showing a clear enrichment of genes linked to serotonin neurotransmission and neurodevelopmental processes.
Conclusions: This study has allowed the identification of several GxE-environment interactions involved in the risk of presenting a FEP. Our results highlight the importance of serotonin neurotransmission interacting with certain environmental stimuli. The serotoninergic system may be playing a key role in the regulatory network of stress and other systems implicated in the emergence and development of psychotic disorders.
Keywords: First episodes psychosis; Gene-environment interaction; Predictive model; Schizophrenia.
Copyright © 2017 Elsevier B.V. All rights reserved.
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