DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential - PubMed (original) (raw)
Review
. 2017 May;18(5):279-284.
doi: 10.1038/nrm.2017.3. Epub 2017 Feb 22.
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- PMID: 28225080
- DOI: 10.1038/nrm.2017.3
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Review
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Robert Hänsel-Hertsch et al. Nat Rev Mol Cell Biol. 2017 May.
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Abstract
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.
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