AMPK signalling in health and disease - PubMed (original) (raw)

Review

doi: 10.1016/j.ceb.2017.01.005. Epub 2017 Feb 21.

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Review

AMPK signalling in health and disease

David Carling. Curr Opin Cell Biol. 2017 Apr.

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Abstract

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.

Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

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