Cannabidiol: State of the art and new challenges for therapeutic applications - PubMed (original) (raw)

Review

doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22.

Anna Maria Malfitano [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Elena Ciaglia [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Anna Lamberti [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Roberta Ranieri [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Gaia Cuomo [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Mario Abate [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Giorgio Faggiana [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Maria Chiara Proto 3, Donatella Fiore 3, Chiara Laezza 4, Maurizio Bifulco [ 5](#full-view-affiliation-5 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy; Corporea, Fondazione Idis-Città della Scienza, Naples, Italy. Electronic address: mbifulco@unisa.it.")

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Review

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al. Pharmacol Ther. 2017 Jul.

Abstract

Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.

Keywords: Cancer; Cannabidiol; Cannabis; Endocannabinoid system; Neurological diseases.

Copyright © 2017. Published by Elsevier Inc.

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