Cannabidiol: State of the art and new challenges for therapeutic applications - PubMed (original) (raw)
Review
doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22.
Anna Maria Malfitano [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Elena Ciaglia [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Anna Lamberti [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Roberta Ranieri [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Gaia Cuomo [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Mario Abate [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Giorgio Faggiana [ 2](#full-view-affiliation-2 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy."), Maria Chiara Proto 3, Donatella Fiore 3, Chiara Laezza 4, Maurizio Bifulco [ 5](#full-view-affiliation-5 "Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Italy; Corporea, Fondazione Idis-Città della Scienza, Naples, Italy. Electronic address: mbifulco@unisa.it.")
Affiliations
- PMID: 28232276
- DOI: 10.1016/j.pharmthera.2017.02.041
Review
Cannabidiol: State of the art and new challenges for therapeutic applications
Simona Pisanti et al. Pharmacol Ther. 2017 Jul.
Abstract
Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.
Keywords: Cancer; Cannabidiol; Cannabis; Endocannabinoid system; Neurological diseases.
Copyright © 2017. Published by Elsevier Inc.
Similar articles
- Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol.
Bielawiec P, Harasim-Symbor E, Chabowski A. Bielawiec P, et al. Front Endocrinol (Lausanne). 2020 Mar 4;11:114. doi: 10.3389/fendo.2020.00114. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32194509 Free PMC article. Review. - A systematic review of the antipsychotic properties of cannabidiol in humans.
Iseger TA, Bossong MG. Iseger TA, et al. Schizophr Res. 2015 Mar;162(1-3):153-61. doi: 10.1016/j.schres.2015.01.033. Epub 2015 Feb 7. Schizophr Res. 2015. PMID: 25667194 Review. - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G. Scuderi C, et al. Phytother Res. 2009 May;23(5):597-602. doi: 10.1002/ptr.2625. Phytother Res. 2009. PMID: 18844286 Review. - Cannabis: Drug of Abuse and Therapeutic Agent, Two Sides of the Same Coin.
Canseco-Alba A, Rodríguez-Manzo G. Canseco-Alba A, et al. Rev Invest Clin. 2023;75(3):105-128. doi: 10.24875/RIC.23000112. Rev Invest Clin. 2023. PMID: 37441766 Review. - Neurological Aspects of Medical Use of Cannabidiol.
Mannucci C, Navarra M, Calapai F, Spagnolo EV, Busardò FP, Cas RD, Ippolito FM, Calapai G. Mannucci C, et al. CNS Neurol Disord Drug Targets. 2017;16(5):541-553. doi: 10.2174/1871527316666170413114210. CNS Neurol Disord Drug Targets. 2017. PMID: 28412918 Review.
Cited by
- Unleashing the therapeutic role of cannabidiol in dentistry.
Mulla SA, Patil A, Mali S, Jain AK, Jaiswal H, Sawant HR, Arvind R, Singh S. Mulla SA, et al. J Oral Biol Craniofac Res. 2024 Sep-Oct;14(5):649-654. doi: 10.1016/j.jobcr.2024.09.001. Epub 2024 Sep 7. J Oral Biol Craniofac Res. 2024. PMID: 39296277 Free PMC article. Review. - Substitution of Animal Fat and Sodium Nitrite with Hemp Seed Oil: Effect on the Nutritional Value, Sensory Characteristics, and Shelf Life of Fermented Salami.
Papatzimos G, Basdagianni Z, Kasapidou E. Papatzimos G, et al. Foods. 2024 Aug 18;13(16):2584. doi: 10.3390/foods13162584. Foods. 2024. PMID: 39200511 Free PMC article. - Cannabinoids and triple-negative breast cancer treatment.
Dobovišek L, Borštnar S, Debeljak N, Kranjc Brezar S. Dobovišek L, et al. Front Immunol. 2024 Aug 8;15:1386548. doi: 10.3389/fimmu.2024.1386548. eCollection 2024. Front Immunol. 2024. PMID: 39176080 Free PMC article. Review. - Enhancing the porosity of chitosan sponges with CBD by adding antimicrobial violacein.
Chelminiak-Dudkiewicz D, Wujak M, Mlynarczyk DT, Dlugaszewska J, Mylkie K, Smolarkiewicz-Wyczachowski A, Ziegler-Borowska M. Chelminiak-Dudkiewicz D, et al. Heliyon. 2024 Jul 31;10(15):e35389. doi: 10.1016/j.heliyon.2024.e35389. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39165973 Free PMC article. - From 'Farm to Fork': Exploring the Potential of Nutrient-Rich and Stress-Resilient Emergent Crops for Sustainable and Healthy Food in the Mediterranean Region in the Face of Climate Change Challenges.
Matías J, Rodríguez MJ, Carrillo-Vico A, Casals J, Fondevilla S, Haros CM, Pedroche J, Aparicio N, Fernández-García N, Aguiló-Aguayo I, Soler-Rivas C, Caballero PA, Morte A, Rico D, Reguera M; NutriCrop Spanish Consortium/Group. Matías J, et al. Plants (Basel). 2024 Jul 11;13(14):1914. doi: 10.3390/plants13141914. Plants (Basel). 2024. PMID: 39065441 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous