Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA - PubMed (original) (raw)

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

P J Farrell et al. Proc Natl Acad Sci U S A. 1978 Dec.

Abstract

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kinase and the endonuclease have been partially purified from interferon-treated Ehrlich ascites tumor cells. The 2',5'-oligoadenylates [pppA(2'p5'A)n], found found earlier to be mediators in the activation of the endonuclease by double-stranded RNA, are not mediators in the activation of the protein kinase by double-stranded RNA.

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