Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors - PubMed (original) (raw)

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors

M L Mucenski et al. Mol Cell Biol. 1988 Jan.

Abstract

AKXD-23 recombinant inbred mice develop myeloid tumors at a high frequency, unlike other AKXD recombinant inbred strains which develop B-cell lymphomas, T-cell lymphomas, or both. AKXD-23 myeloid tumors are monoclonal, and their DNA contains somatically acquired proviruses, suggesting that they are retrovirally induced. We identified a common site of ecotropic proviral integration that is present in the DNA of all AKXD-23 myeloid tumors that were analyzed and in the DNA of all myeloid tumors that occur in AKXD strains other than AKXD-23. We designated this locus Evi-1 (ecotropic viral integration site 1). Rearrangements in the Evi-1 locus were also detected in the DNA of a number of myeloid tumors and myeloid cell lines isolated from strains other than AKXD. In contrast, few Evi-1 rearrangements were detected in the DNA of T- or B-cell tumors. Evi-1 may thus identify a new proto-oncogene locus that is involved in myeloid disease.

PubMed Disclaimer

Similar articles

• Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.
  Justice MJ, Morse HC 3rd, Jenkins NA, Copeland NG. Justice MJ, et al. J Virol. 1994 Mar;68(3):1293-300. doi: 10.1128/JVI.68.3.1293-1300.1994. J Virol. 1994. PMID: 8107195 Free PMC article.
• Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors.
  Mucenski ML, Taylor BA, Copeland NG, Jenkins NA. Mucenski ML, et al. Oncogene Res. 1988 Feb;2(3):219-33. Oncogene Res. 1988. PMID: 2897103
• Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice.
  Mucenski ML, Taylor BA, Copeland NG, Jenkins NA. Mucenski ML, et al. J Virol. 1987 Sep;61(9):2929-33. doi: 10.1128/JVI.61.9.2929-2933.1987. J Virol. 1987. PMID: 3039180 Free PMC article.
• The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review).
  Yuan X, Wang X, Bi K, Jiang G. Yuan X, et al. Int J Oncol. 2015 Dec;47(6):2028-36. doi: 10.3892/ijo.2015.3207. Epub 2015 Oct 15. Int J Oncol. 2015. PMID: 26496831 Review.
• Retroviral integration in murine myeloid tumors to identify Evi-1, a novel locus encoding a zinc-finger protein.
  Copeland NG, Jenkins NA. Copeland NG, et al. Adv Cancer Res. 1990;54:141-57. doi: 10.1016/s0065-230x(08)60810-6. Adv Cancer Res. 1990. PMID: 2105003 Review. No abstract available.

Cited by

• EVI1-mediated Programming of Normal and Malignant Hematopoiesis.
  Lux S, Milsom MD. Lux S, et al. Hemasphere. 2023 Oct 4;7(10):e959. doi: 10.1097/HS9.0000000000000959. eCollection 2023 Oct. Hemasphere. 2023. PMID: 37810550 Free PMC article. Review.
• Mds1CreERT2, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells.
  Zhang Y, McGrath KE, Ayoub E, Kingsley PD, Yu H, Fegan K, McGlynn KA, Rudzinskas S, Palis J, Perkins AS. Zhang Y, et al. Cell Rep. 2021 Aug 17;36(7):109562. doi: 10.1016/j.celrep.2021.109562. Cell Rep. 2021. PMID: 34407416 Free PMC article.
• EVI1 dysregulation: impact on biology and therapy of myeloid malignancies.
  Birdwell C, Fiskus W, Kadia TM, DiNardo CD, Mill CP, Bhalla KN. Birdwell C, et al. Blood Cancer J. 2021 Mar 22;11(3):64. doi: 10.1038/s41408-021-00457-9. Blood Cancer J. 2021. PMID: 33753715 Free PMC article. Review.
• EVI1 in Leukemia and Solid Tumors.
  Liang B, Wang J. Liang B, et al. Cancers (Basel). 2020 Sep 18;12(9):2667. doi: 10.3390/cancers12092667. Cancers (Basel). 2020. PMID: 32962037 Free PMC article. Review.
• EVI1 as a Marker for Lymph Node Metastasis in HNSCC.
  Idel C, Ribbat-Idel J, Kuppler P, Krupar R, Offermann A, Vogel W, Rades D, Kirfel J, Wollenberg B, Perner S. Idel C, et al. Int J Mol Sci. 2020 Jan 28;21(3):854. doi: 10.3390/ijms21030854. Int J Mol Sci. 2020. PMID: 32013033 Free PMC article.

References

1. 1. J Natl Cancer Inst. 1969 Oct;43(4):963-82 - PubMed
2. 1. J Virol. 1985 Sep;55(3):862-6 - PubMed
3. 1. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6687-91 - PubMed
4. 1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
5. 1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Taylor & Francis

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)