[Red yeast-rice-induced muscular injuries: Analysis of French pharmacovigilance database and literature review] - PubMed (original) (raw)
. 2023 Sep-Oct;78(5S):S31-S40.
doi: 10.2515/therapie/2015053. Epub 2016 Oct 27.
[Article in French]
Affiliations
- PMID: 28277227
- DOI: 10.2515/therapie/2015053
[Red yeast-rice-induced muscular injuries: Analysis of French pharmacovigilance database and literature review]
[Article in French]
Christelle Philibert et al. Therapie. 2023 Sep-Oct.
Abstract
Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia. Recent studies seem to show good efficacy of the RYR, however, our work reports the existence of related muscular disorders. In addition, dietary supplements currently available on the market may show considerable variability of formulation and/or the presence of contaminants. When clinicobiological disorders occur, physicians should consider the eventual use of an herbal treatment.
Keywords: Atteintes musculaires; Levure de riz rouge; Muscular injuries; Phytotherapy; Phytothérapie; Red yeast rice; Statin; Statine.
Copyright © 2014 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.
Similar articles
- Scientific opinion on the safety of monacolins in red yeast rice.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Andrade RJ, Fortes C, Mosesso P, Restani P, Pizzo F, Smeraldi C, Wright M. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), et al. EFSA J. 2018 Aug 3;16(8):e05368. doi: 10.2903/j.efsa.2018.5368. eCollection 2018 Aug. EFSA J. 2018. PMID: 32626016 Free PMC article. - Stable isotope ratio analysis for authentication of red yeast rice.
Perini M, Carbone G, Camin F. Perini M, et al. Talanta. 2017 Nov 1;174:228-233. doi: 10.1016/j.talanta.2017.05.057. Epub 2017 May 23. Talanta. 2017. PMID: 28738573 - Red yeast rice for the treatment of dyslipidemia.
Burke FM. Burke FM. Curr Atheroscler Rep. 2015 Apr;17(4):495. doi: 10.1007/s11883-015-0495-8. Curr Atheroscler Rep. 2015. PMID: 25728312 Review. - Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: Chemometrics application.
Avula B, Cohen PA, Wang YH, Sagi S, Feng W, Wang M, Zweigenbaum J, Shuangcheng M, Khan IA. Avula B, et al. J Pharm Biomed Anal. 2014 Nov;100:243-253. doi: 10.1016/j.jpba.2014.07.039. Epub 2014 Aug 9. J Pharm Biomed Anal. 2014. PMID: 25168220 - Red Yeast Rice Plus Berberine: Practical Strategy for Promoting Vascular and Metabolic Health.
McCarty MF, O'Keefe JH, DiNicolantonio JJ. McCarty MF, et al. Altern Ther Health Med. 2015;21 Suppl 2:40-5. Altern Ther Health Med. 2015. PMID: 26308759 Review.
Cited by
- Efficacy of Letrozole Combined with Urinary Gonadotropin for Ovulation Induction in Endocrine Abnormal Infertility Patients: A Retrospective Single-Center, Case-Control Study.
Peng H, Yuan B, Mao J, Wang J, Luo S. Peng H, et al. Comput Math Methods Med. 2022 Jul 11;2022:5363754. doi: 10.1155/2022/5363754. eCollection 2022. Comput Math Methods Med. 2022. PMID: 35860181 Free PMC article. Retracted. - Nutraceutical Combinations in Hypercholesterolemia: Evidence from Randomized, Placebo-Controlled Clinical Trials.
Protic O, Bonfigli AR, Antonicelli R. Protic O, et al. Nutrients. 2021 Sep 8;13(9):3128. doi: 10.3390/nu13093128. Nutrients. 2021. PMID: 34579005 Free PMC article. Review. - Scientific opinion on the safety of monacolins in red yeast rice.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Andrade RJ, Fortes C, Mosesso P, Restani P, Pizzo F, Smeraldi C, Wright M. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), et al. EFSA J. 2018 Aug 3;16(8):e05368. doi: 10.2903/j.efsa.2018.5368. eCollection 2018 Aug. EFSA J. 2018. PMID: 32626016 Free PMC article. - Mini-review: medication safety of red yeast rice products.
Farkouh A, Baumgärtel C. Farkouh A, et al. Int J Gen Med. 2019 Apr 30;12:167-171. doi: 10.2147/IJGM.S202446. eCollection 2019. Int J Gen Med. 2019. PMID: 31118742 Free PMC article. - Adverse Events to Food Supplements Containing Red Yeast Rice: Comparative Analysis of FAERS and CAERS Reporting Systems.
Raschi E, Girardi A, Poluzzi E, Forcesi E, Menniti-Ippolito F, Mazzanti G, De Ponti F. Raschi E, et al. Drug Saf. 2018 Aug;41(8):745-752. doi: 10.1007/s40264-018-0661-3. Drug Saf. 2018. PMID: 29582393
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources