Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities - PubMed (original) (raw)
Review
. 2017 Mar 8;93(5):1015-1034.
doi: 10.1016/j.neuron.2017.01.022.
Angeleen Fleming 1, Andrea Caricasole 2, Carla F Bento 1, Stephen P Andrews 2, Avraham Ashkenazi 1, Jens Füllgrabe 1, Anne Jackson 1, Maria Jimenez Sanchez 1, Cansu Karabiyik 1, Floriana Licitra 1, Ana Lopez Ramirez 1, Mariana Pavel 1, Claudia Puri 1, Maurizio Renna 1, Thomas Ricketts 1, Lars Schlotawa 1, Mariella Vicinanza 1, Hyeran Won 1, Ye Zhu 1, John Skidmore 2, David C Rubinsztein 3
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- PMID: 28279350
- DOI: 10.1016/j.neuron.2017.01.022
Free article
Review
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Fiona M Menzies et al. Neuron. 2017.
Free article
Abstract
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with intracytoplasmic aggregate-prone protein accumulation as well as other roles, including in neuronal stem cell differentiation. We then describe how autophagy may be affected in a range of neurodegenerative diseases. Finally, we describe how autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions and consider possible pathways and druggable targets that may be suitable for this objective.
Keywords: Alzheimer’s disease; Huntington’s disease; Parkinson’s disease; autophagy; dementia; lysosome; motor neuron disease; neurodegeneration; tau.
Copyright © 2017 Elsevier Inc. All rights reserved.
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