Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus - PubMed (original) (raw)
Affiliations
- PMID: 2827957
Review
Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus
M Rodriguez et al. Crit Rev Immunol. 1987.
Abstract
Theiler's murine encephalomyelitis virus (TMEV) causes immune-mediated demyelination in susceptible mice which is similar to human demyelinating disorders such as multiple sclerosis. In addition, the picornavirus persists within the central nervous system throughout the course of the chronic demyelinating disease. This article reviews the neuropathology, virology, immunology, and molecular biology of the model system. We analyze the possible mechanisms by which this virus induces demyelination and persists in the nervous system. Finally, we provide a hypothesis that the specificity of primary white matter destruction in the TMEV model depends on immune-sensitized cells which interact with viral antigen plus major histocompatibility complex (MHC) antigens on the surfaces of oligodendrocytes or myelin sheaths.
Similar articles
- Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin.
Rodriguez M, Dunkel AJ, Thiemann RL, Leibowitz J, Zijlstra M, Jaenisch R. Rodriguez M, et al. J Immunol. 1993 Jul 1;151(1):266-76. J Immunol. 1993. PMID: 8326128 - Theiler's virus infection: a model for multiple sclerosis.
Friedmann A, Lorch Y. Friedmann A, et al. Prog Med Virol. 1985;31:43-83. Prog Med Virol. 1985. PMID: 3881806 Review. No abstract available.
Cited by
- CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support.
Johnson HL, Chen Y, Jin F, Hanson LM, Gamez JD, Pirko I, Johnson AJ. Johnson HL, et al. J Immunol. 2012 Aug 15;189(4):1937-45. doi: 10.4049/jimmunol.1200658. Epub 2012 Jul 6. J Immunol. 2012. PMID: 22772449 Free PMC article. - Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination.
McGavern DB, Zoecklein L, Sathornsumetee S, Rodriguez M. McGavern DB, et al. Brain Res. 2000 Sep 22;877(2):396-400. doi: 10.1016/s0006-8993(00)02710-4. Brain Res. 2000. PMID: 10986359 Free PMC article. - Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury.
McGavern DB, Murray PD, Rodriguez M. McGavern DB, et al. J Neurosci Res. 1999 Nov 15;58(4):492-504. doi: 10.1002/(sici)1097-4547(19991115)58:4<492::aid-jnr3>3.0.co;2-p. J Neurosci Res. 1999. PMID: 10533042 Free PMC article. - Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis.
Sathornsumetee S, McGavern DB, Ure DR, Rodriguez M. Sathornsumetee S, et al. Am J Pathol. 2000 Oct;157(4):1365-76. doi: 10.1016/S0002-9440(10)64650-0. Am J Pathol. 2000. PMID: 11021839 Free PMC article. - Demyelination initiated by oligodendrocyte apoptosis through enhancing endoplasmic reticulum-mitochondria interactions and Id2 expression after compressed spinal cord injury in rats.
Huang SQ, Tang CL, Sun SQ, Yang C, Xu J, Wang KJ, Lu WT, Huang J, Zhuo F, Qiu GP, Wu XY, Qi W. Huang SQ, et al. CNS Neurosci Ther. 2014 Jan;20(1):20-31. doi: 10.1111/cns.12155. Epub 2013 Aug 13. CNS Neurosci Ther. 2014. PMID: 23937638 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Research Materials