Pre-metastatic niches: organ-specific homes for metastases - PubMed (original) (raw)

Review

. 2017 May;17(5):302-317.

doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17.

Haiying Zhang 1, Irina R Matei 1, Bruno Costa-Silva 1 3, Ayuko Hoshino 1, Goncalo Rodrigues 1 4, Bethan Psaila 5, Rosandra N Kaplan 6, Jacqueline F Bromberg 7, Yibin Kang 8 9, Mina J Bissell 10, Thomas R Cox 11, Amato J Giaccia 12, Janine T Erler 13, Sachie Hiratsuka 14, Cyrus M Ghajar 15, David Lyden 1 16

Affiliations

• PMID: 28303905
• DOI: 10.1038/nrc.2017.6

Free article

Review

Pre-metastatic niches: organ-specific homes for metastases

Héctor Peinado et al. Nat Rev Cancer. 2017 May.

Free article

Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

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