Heteroplasmy in mice with deletion of a large coding region of mitochondrial DNA - PubMed (original) (raw)

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM. Hirose M, et al. Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6. Sci Rep. 2018. PMID: 29651131 Free PMC article.