A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family - PubMed (original) (raw)

. 2017 Mar 23;169(1):58-71.e14.

doi: 10.1016/j.cell.2017.03.002.

Richard Berry 2, Mir Munir A Rahim 3, Johanna J Reichel 4, Branka Popović 4, Miho Tanaka 1, Zhihui Fu 5, Gautham R Balaji 2, Timothy N H Lau 1, Megan M Tu 3, Christina L Kirkham 1, Ahmad Bakur Mahmoud 6, Aruz Mesci 1, Astrid Krmpotić 4, David S J Allan 1, Andrew P Makrigiannis 7, Stipan Jonjić 8, Jamie Rossjohn 9, James R Carlyle 10

Affiliations

• PMID: 28340350
• DOI: 10.1016/j.cell.2017.03.002

Free article

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

Oscar A Aguilar et al. Cell. 2017.

Free article

Abstract

Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1.1) receptors. This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor. However, m12 also interacts with the activating NKR-P1A/C receptors to counterbalance m12 decoy function. Structural analyses reveal that m12 sequesters a large NKR-P1 surface area via a "polar claw" mechanism. Polymorphisms in, and ablation of, the viral m12 protein and host NKR-P1B/C alleles impact NK cell responses in vivo. Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls the evolutionary balance of immune recognition during host-pathogen interplay.

Keywords: NK1.1 ligand; Natural killer cell; host-pathogen interactions; murine cytomegalovirus; viral immune evasion.

Copyright © 2017 Elsevier Inc. All rights reserved.

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