Enhancement of Ia synaptic transmission following muscle nerve section: dependence upon protein synthesis - PubMed (original) (raw)
Enhancement of Ia synaptic transmission following muscle nerve section: dependence upon protein synthesis
Y Miyata et al. Neurosci Res. 1988 Apr.
Abstract
Monosynaptic excitatory postsynaptic potentials (EPSPs) were recorded from the triceps surae motoneurons in the rat. Two to 3 weeks after section of the medial gastrocnemius (MG) nerve, Ia EPSPs evoked by stimulation of the MG nerve were significantly depressed, as reported previously. However, the MG EPSP amplitude significantly increased within 24 h, reaching a maximum on the 3rd day after axotomy. This increase was prevented by actinomycin-D treatment, indicating that the synaptic enhancement is dependent upon protein synthesis. When disuse of sensory fibers was induced without injuring the muscle nerve, the degree of synaptic enhancement was similar to that after axotomy. Therefore, the enhancement of central synaptic transmission shortly after axotomy is due to the loss of electrical activity, but not due to the axon reaction of the Ia sensory neurons to injury. It is postulated that the presence of some factor in Ia sensory fibers enhances synaptic transmission, while electrical activity of the neurons antagonizes the action of this factor.
Similar articles
- Disuse-induced enhancement of Ia synaptic transmission in spinal motoneurons of the rat.
Manabe T, Kaneko S, Kuno M. Manabe T, et al. J Neurosci. 1989 Jul;9(7):2455-61. doi: 10.1523/JNEUROSCI.09-07-02455.1989. J Neurosci. 1989. PMID: 2545838 Free PMC article. - Effects of chronic spinalization on ankle extensor motoneurons. I. Composite monosynaptic Ia EPSPs in four motoneuron pools.
Hochman S, McCrea DA. Hochman S, et al. J Neurophysiol. 1994 Apr;71(4):1452-67. doi: 10.1152/jn.1994.71.4.1452. J Neurophysiol. 1994. PMID: 8035227 - Reaction of synapses on motoneurones to section and restoration of peripheral sensory connexions in the cat.
Goldring JM, Kuno M, Núñez R, Snider WD. Goldring JM, et al. J Physiol. 1980 Dec;309:185-98. doi: 10.1113/jphysiol.1980.sp013503. J Physiol. 1980. PMID: 7252863 Free PMC article. - Physiological aspects of synaptic plasticity: the Ia/motoneuron connection as a model.
Mendell LM. Mendell LM. Adv Neurol. 1988;47:337-60. Adv Neurol. 1988. PMID: 3278522 Review. - Partitioning of monosynaptic Ia excitatory postsynaptic potentials in the motor nucleus of the cat lateral gastrocnemius muscle.
Vanden Noven S, Hamm TM, Stuart DG. Vanden Noven S, et al. J Neurophysiol. 1986 Mar;55(3):569-86. doi: 10.1152/jn.1986.55.3.569. J Neurophysiol. 1986. PMID: 3514815 Review.
Cited by
- Central suppression of regenerated proprioceptive afferents.
Haftel VK, Bichler EK, Wang QB, Prather JF, Pinter MJ, Cope TC. Haftel VK, et al. J Neurosci. 2005 May 11;25(19):4733-42. doi: 10.1523/JNEUROSCI.4895-04.2005. J Neurosci. 2005. PMID: 15888649 Free PMC article. - Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm.
Alvarez FJ, Rotterman TM, Akhter ET, Lane AR, English AW, Cope TC. Alvarez FJ, et al. Front Mol Neurosci. 2020 Apr 30;13:68. doi: 10.3389/fnmol.2020.00068. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32425754 Free PMC article. Review. - CNS neurotrophins are biologically active and expressed by multiple cell types.
Riley CP, Cope TC, Buck CR. Riley CP, et al. J Mol Histol. 2004 Nov;35(8-9):771-83. doi: 10.1007/s10735-004-0778-9. J Mol Histol. 2004. PMID: 15609090 - Short-term afferent axotomy increases both strength and depression at Ia-motoneuron synapses in Rat.
Seburn KL, Cope TC. Seburn KL, et al. J Neurosci. 1998 Feb 1;18(3):1142-7. doi: 10.1523/JNEUROSCI.18-03-01142.1998. J Neurosci. 1998. PMID: 9437034 Free PMC article. - Enhanced transmission at a spinal synapse triggered in vivo by an injury signal independent of altered synaptic activity.
Bichler EK, Nakanishi ST, Wang QB, Pinter MJ, Rich MM, Cope TC. Bichler EK, et al. J Neurosci. 2007 Nov 21;27(47):12851-9. doi: 10.1523/JNEUROSCI.1997-07.2007. J Neurosci. 2007. PMID: 18032657 Free PMC article.