Resistance to Ceftazidime-Avibactam in Klebsiella pneumoniae Due to Porin Mutations and the Increased Expression of KPC-3 - PubMed (original) (raw)

Resistance to Ceftazidime-Avibactam in Klebsiella pneumoniae Due to Porin Mutations and the Increased Expression of KPC-3

Romney M Humphries et al. Antimicrob Agents Chemother. 2017.

No abstract available

Keywords: KPC; OmpK35; OmpK36; ceftazidime-avibactam; resistance.

PubMed Disclaimer

Similar articles

• Ceftazidime-Avibactam Resistance Associated with Increased _bla_KPC-3 Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258 Klebsiella pneumoniae.
  Coppi M, Di Pilato V, Monaco F, Giani T, Conaldi PG, Rossolini GM. Coppi M, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01816-19. doi: 10.1128/AAC.01816-19. Print 2020 Mar 24. Antimicrob Agents Chemother. 2020. PMID: 31964792 Free PMC article.
• Genomic characterization of a KPC-23-producing Klebsiella pneumoniae ST258 clinical isolate resistant to ceftazidime-avibactam.
  Galani I, Antoniadou A, Karaiskos I, Kontopoulou K, Giamarellou H, Souli M. Galani I, et al. Clin Microbiol Infect. 2019 Jun;25(6):763.e5-763.e8. doi: 10.1016/j.cmi.2019.03.011. Epub 2019 Mar 28. Clin Microbiol Infect. 2019. PMID: 30928562
• Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae.
  Haidar G, Clancy CJ, Chen L, Samanta P, Shields RK, Kreiswirth BN, Nguyen MH. Haidar G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00642-17. doi: 10.1128/AAC.00642-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28630202 Free PMC article.
• Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview.
  Hobson CA, Pierrat G, Tenaillon O, Bonacorsi S, Bercot B, Jaouen E, Jacquier H, Birgy A. Hobson CA, et al. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0044722. doi: 10.1128/aac.00447-22. Epub 2022 Aug 18. Antimicrob Agents Chemother. 2022. PMID: 35980232 Free PMC article. Review.
• Ceftazidime-avibactam.
  Matesanz M, Mensa J. Matesanz M, et al. Rev Esp Quimioter. 2021 Sep;34 Suppl 1(Suppl1):38-40. doi: 10.37201/req/s01.11.2021. Epub 2021 Sep 30. Rev Esp Quimioter. 2021. PMID: 34598423 Free PMC article. Review.

Cited by

• In vivo Selection of Imipenem Resistance Among Ceftazidime-Avibactam-Resistant, Imipenem-Susceptible Klebsiella pneumoniae Isolate With KPC-33 Carbapenemase.
  Wang C, Zhao J, Liu Z, Sun A, Sun L, Li B, Lu B, Liu Y, Cao B. Wang C, et al. Front Microbiol. 2021 Sep 23;12:727946. doi: 10.3389/fmicb.2021.727946. eCollection 2021. Front Microbiol. 2021. PMID: 34630354 Free PMC article.
• Empirical antimicrobial treatment in haemato-/oncological patients with neutropenic sepsis.
  Vossen MG, Milacek C, Thalhammer F. Vossen MG, et al. ESMO Open. 2018 Jun 13;3(3):e000348. doi: 10.1136/esmoopen-2018-000348. eCollection 2018. ESMO Open. 2018. PMID: 29942661 Free PMC article. Review.
• Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy is Associated With an Increase in blaNDM-5 Copy Number and Gene Expression.
  Simner PJ, Mostafa HH, Bergman Y, Ante M, Tekle T, Adebayo A, Beisken S, Dzintars K, Tamma PD. Simner PJ, et al. Clin Infect Dis. 2022 Aug 24;75(1):47-54. doi: 10.1093/cid/ciab888. Clin Infect Dis. 2022. PMID: 34618008 Free PMC article.
• Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae.
  Sun D, Rubio-Aparicio D, Nelson K, Dudley MN, Lomovskaya O. Sun D, et al. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01694-17. doi: 10.1128/AAC.01694-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 29038260 Free PMC article.
• Structural Basis and Binding Kinetics of Vaborbactam in Class A β-Lactamase Inhibition.
  Pemberton OA, Tsivkovski R, Totrov M, Lomovskaya O, Chen Y. Pemberton OA, et al. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00398-20. doi: 10.1128/AAC.00398-20. Print 2020 Sep 21. Antimicrob Agents Chemother. 2020. PMID: 32778546 Free PMC article.

References

1. 1. Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A. 2015. First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate. Antimicrob Agents Chemother 59:6605–6607. doi:10.1128/AAC.01165-15. - DOI - PMC - PubMed
2. 1. Yang S, Hemarajata P, Hindler J, Li F, Adisetiyo H, Aldrovandi G, Sebra R, Kasarskis A, MacCannell D, Didelot X, Humphries RM. 2017. Evolution and transmission of carbapenem-resistant Klebsiella pneumoniae expressing the blaOXA-232 gene during an institutional outbreak associated with endoscopic retrograde cholangiopancreatography. Clin Infect Dis 64:894–901. doi:10.1093/cid/ciw876. - DOI - PubMed
3. 1. Bowers JR, Kitchel B, Driebe EM, MacCannell DR, Roe C, Lemmer D, de Man T, Rasheed JK, Engelthaler DM, Keim P, Limbago BM. 2015. Genomic analysis of the emergence and rapid global dissemination of the clonal group 258 Klebsiella pneumoniae pandemic. PLoS One 10:e0133727. doi:10.1371/journal.pone.0133727. - DOI - PMC - PubMed
4. 1. Shields RK, Clancy CJ, Hao B, Chen L, Press EG, Iovine NM, Kreiswirth BN, Nguyen MH. 2015. Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum beta-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae. Antimicrob Agents Chemother 59:5793–5797. doi:10.1128/AAC.00548-15. - DOI - PMC - PubMed
5. 1. Naas T, Cuzon G, Truong HV, Nordmann P. 2012. Role of ISKpn7 and deletions in blaKPC gene expression. Antimicrob Agents Chemother 56:4753–4759. doi:10.1128/AAC.00334-12. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • SILVA