Interferon-beta 2/interleukin 6 is a co-stimulant for human T lymphocytes - PubMed (original) (raw)
. 1988 Sep 1;141(5):1556-62.
Affiliations
- PMID: 2842397
Interferon-beta 2/interleukin 6 is a co-stimulant for human T lymphocytes
G Tosato et al. J Immunol. 1988.
Abstract
IFN-beta 2/IL-6 promotes the proliferation of human peripheral blood T cells in the presence of either PHA or Con A. This effect is observed with highly purified T cells and is masked by the addition of as few as 2% monocytes, suggesting that accessory cells are not required and that IFN-beta 2/IL-6 acts directly on the T cells. Both T4-positive and T8-positive cells respond to IFN-beta 2/IL-6 plus PHA. Studies of the time requirements of IFN-beta 2/IL-6 and of PHA in the response of T cells show that optimal co-stimulation occurs when both IFN-beta 2/IL-6 and PHA are added together at the outset of culture, suggesting that IFN-beta 2/IL-6 acts predominantly on resting T cells. Unlike T cell proliferation induced by IL-2, T cell proliferation induced by IFN-beta 2/IL-6 is not blocked by antibodies to the IL-2 R, suggesting that IFN-beta 2/IL-6 does not act by stimulating IL-2 production. Thus, in addition to its previously reported properties, IFN-beta 2/IL-6 stimulates T cells in the presence of mitogen, and may prove to be of considerable importance in the physiologic activation of T cells.
Similar articles
- The neglected role of type I interferon in the T-cell response: implications for its clinical use.
Belardelli F, Gresser I. Belardelli F, et al. Immunol Today. 1996 Aug;17(8):369-72. doi: 10.1016/0167-5699(96)10027-X. Immunol Today. 1996. PMID: 8783497 Review. - T-cell adjuvants.
Hadden JW. Hadden JW. Int J Immunopharmacol. 1994 Sep;16(9):703-10. doi: 10.1016/0192-0561(94)90090-6. Int J Immunopharmacol. 1994. PMID: 7806429 Review.
Cited by
- Amniotic fluid interleukin 6 in preterm labor. Association with infection.
Romero R, Avila C, Santhanam U, Sehgal PB. Romero R, et al. J Clin Invest. 1990 May;85(5):1392-400. doi: 10.1172/JCI114583. J Clin Invest. 1990. PMID: 2332497 Free PMC article. - Intraabdominal infections: classification, mortality, scoring and pathophysiology.
Holzheimer RG, Muhrer KH, L'Allemand N, Schmidt T, Henneking K. Holzheimer RG, et al. Infection. 1991 Nov-Dec;19(6):447-52. doi: 10.1007/BF01726463. Infection. 1991. PMID: 1816119 - Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens.
Yachie A, Takano N, Ohta K, Uehara T, Fujita S, Miyawaki T, Taniguchi N. Yachie A, et al. Infect Immun. 1992 Mar;60(3):749-53. doi: 10.1128/iai.60.3.749-753.1992. Infect Immun. 1992. PMID: 1541547 Free PMC article. - Induction of antitumor immunity and treatment of preestablished tumor by interleukin-6-gene-transfected melanoma cells combined with low-dose interleukin-2.
Cao X, Zhang W, Gu S, Yu Y, Tao Q, Ye T. Cao X, et al. J Cancer Res Clin Oncol. 1995;121(12):721-8. doi: 10.1007/BF01213318. J Cancer Res Clin Oncol. 1995. PMID: 7499443 - Interleukin-6 and acute-phase proteins in head and neck cancer.
Gallo O, Gori AM, Attanasio M, Martini F, Giusti B, Brunelli T, Gallina E. Gallo O, et al. Eur Arch Otorhinolaryngol. 1995;252(3):159-62. doi: 10.1007/BF00178104. Eur Arch Otorhinolaryngol. 1995. PMID: 7544987