Lymphocyte activation by HIV-1 envelope glycoprotein - PubMed (original) (raw)
. 1988 Sep 29;335(6189):445-8.
doi: 10.1038/335445a0.
Affiliations
- PMID: 2843775
- DOI: 10.1038/335445a0
Lymphocyte activation by HIV-1 envelope glycoprotein
H Kornfeld et al. Nature. 1988.
Abstract
Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.
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