MicroRNA regulation of extracellular matrix components in the process of atherosclerotic plaque destabilization - PubMed (original) (raw)

Review

. 2017 Jul;44(7):711-718.

doi: 10.1111/1440-1681.12772.

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Review

MicroRNA regulation of extracellular matrix components in the process of atherosclerotic plaque destabilization

Michal Kowara et al. Clin Exp Pharmacol Physiol. 2017 Jul.

Abstract

The process of atherosclerotic plaque destabilization, leading to myocardial infarction, is still not fully understood. The pathway - composed of structural and regulatory proteins of the extracellular matrix (ECM) such as collagen, elastin, small leucine-rich proteoglycans, metalloproteinases, cathepsins and serine proteases - is one potential way of atherosclerotic plaque destabilization. The expression of these proteins is controlled by different microRNA molecules. The goal of this paper is to summarize the current investigations and knowledge about ECM in the process of atherosclerotic plaque destabilization, giving special attention to epigenetic expression regulation by microRNA.

Keywords: RNA interference; atherosclerosis; collagen; extracellular matrix; metalloproteinases.

© 2017 John Wiley & Sons Australia, Ltd.

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