Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas - PubMed (original) (raw)

doi: 10.20892/j.issn.2095-3941.2016.0089.

Xin Song 1, Xue-Ke Zhao 1, Jia Huang 1, Peng Zhang 1, Lu-Wen Wang 1, Hui Meng 1, Jian-Wei Ku 1, Guo-Qiang Kong 1, Tao Jiang 1, Xin-Min Li 1, Xiao-Long Lv 1, Teng Ma 1, Guo Yuan 1, Min-Jie Wu 1, Shou-Jia Hu 1, Shuang Lv 1 3, Tang-Juan Zhang 1, Ling-Fen Ji 1, Zong-Min Fan 1, Neng-Chao Wang 2, Yao-Wen Zhang 2, Fu-You Zhou 2, Li-Dong Wang 1

Affiliations

Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas

Lian-Qun Zhang et al. Cancer Biol Med. 2017 Feb.

Abstract

Objective: : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (ALDH2) gene in a Chinese Han population. We also aimed to investigate_ALDH2_ genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).

Methods: : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671 polymorphism.χ_2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA, and multivariate ordinal logistic regression was used to analyze_ALDH2 genotypic distributions among different groups.

Results: : Compared with_ALDH2_*1/*1 homozygotes,ALDH2*1/*2 and_ALDH2_*2/*2 carriers did not increase the risk for GCA in the Chinese Han population (P_>0.05). Interestingly, the ratio of homozygous or heterozygous_ALDH2 *2 carriers in high-incidence areas for both GCA and ESCC was lower than that in low-incidence areas (P<0.001).

Conclusions: : Genotypes of rs671 at_ALDH2_ may not increase GCA susceptibility in Chinese Han populations. In addition, the_ALDH2_ genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.

Keywords: ALDH2; Gastric cardia adenocarcinoma; high- and low-incidence areas; rs671.

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