Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria - PubMed (original) (raw)

Review

Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria

Mengqing Xiao et al. Free Radic Biol Med. 2017 Oct.

Abstract

Mitochondrial lipids are essential for maintaining the integrity of mitochondrial membranes and the proper functions of mitochondria. As the "powerhouse" of a cell, mitochondria are also the major cellular source of reactive oxygen species (ROS). Oxidative stress occurs when the antioxidant system is overwhelmed by overproduction of ROS. Polyunsaturated fatty acids in mitochondrial membranes are primary targets for ROS attack, which may lead to lipid peroxidation (LPO) and generation of reactive lipids, such as 4-hydroxynonenal. When mitochondrial lipids are oxidized, the integrity and function of mitochondria may be compromised and this may eventually lead to mitochondrial dysfunction, which has been associated with many human diseases including cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. How mitochondrial lipids are oxidized and the underlying molecular mechanisms and pathophysiological consequences associated with mitochondrial LPO remain poorly defined. Oxidation of the mitochondria-specific phospholipid cardiolipin and generation of bioactive lipids through mitochondrial LPO has been increasingly recognized as an important event orchestrating apoptosis, metabolic reprogramming of energy production, mitophagy, and immune responses. In this review, we focus on the current understanding of how mitochondrial LPO and generation of bioactive lipid mediators in mitochondria are involved in the modulation of mitochondrial functions in the context of relevant human diseases associated with oxidative stress.

Keywords: 4-hydroxy-2-nonenal (4-HNE); Cancer; Cardiovascular disease; Diabetes; Lipid peroxidation; Mitochondrial dysfunction; Neurodegenerative diseases.

PubMed Disclaimer

Cited by

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α-Ve-Cadherin Pathway.
Rand D, Ravid O, Atrakchi D, Israelov H, Bresler Y, Shemesh C, Omesi L, Liraz-Zaltsman S, Gosselet F, Maskrey TS, Beeri MS, Wipf P, Cooper I. Rand D, et al. Pharmaceutics. 2021 Feb 28;13(3):311. doi: 10.3390/pharmaceutics13030311. Pharmaceutics. 2021. PMID: 33670876 Free PMC article.
A Novel Combination of γ-Tocopherol-Rich Mixture of Tocopherols and Ascorbic Acid Restores Fertility in Cases of Tyrosine Nitration-Associated Male Infertility in Mice.
Scarlata E, Fernandez MC, O'Flaherty C. Scarlata E, et al. Antioxidants (Basel). 2020 Jul 13;9(7):613. doi: 10.3390/antiox9070613. Antioxidants (Basel). 2020. PMID: 32668798 Free PMC article.
Biological Impacts of Reduced Graphene Oxide Affected by Protein Corona Formation.
Coreas R, Castillo C, Li Z, Yan D, Gao Z, Chen J, Bitounis D, Parviz D, Strano MS, Demokritou P, Zhong W. Coreas R, et al. Chem Res Toxicol. 2022 Jul 18;35(7):1244-1256. doi: 10.1021/acs.chemrestox.2c00042. Epub 2022 Jun 15. Chem Res Toxicol. 2022. PMID: 35706338 Free PMC article.
The mechanism of ferroptosis and its related diseases.
Feng S, Tang D, Wang Y, Li X, Bao H, Tang C, Dong X, Li X, Yang Q, Yan Y, Yin Z, Shang T, Zheng K, Huang X, Wei Z, Wang K, Qi S. Feng S, et al. Mol Biomed. 2023 Oct 16;4(1):33. doi: 10.1186/s43556-023-00142-2. Mol Biomed. 2023. PMID: 37840106 Free PMC article. Review.
Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System.
Yang B, Fritsche KL, Beversdorf DQ, Gu Z, Lee JC, Folk WR, Greenlief CM, Sun GY. Yang B, et al. Front Neurol. 2019 Jun 18;10:642. doi: 10.3389/fneur.2019.00642. eCollection 2019. Front Neurol. 2019. PMID: 31275232 Free PMC article. Review.

Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria - PubMed (original) (raw)