Metabolic Teamwork in the Stem Cell Niche - PubMed (original) (raw)

Metabolic Teamwork in the Stem Cell Niche

Jatin Roper et al. Cell Metab. 2017.

Abstract

Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth cells provides lactate to drive mitochondrial oxidative phosphorylation in intestinal stem cells.

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Figures

Figure 1. Metabolic regulation of intestinal stem cell niche homeostasis

Intestinal stem cells (ISCs) and niche Paneth cells (dotted box) reside in the bases of the crypts of Lieberkühn. ISCs differentiate to form all intestinal cell types. Paneth cells support ISC function by producing growth factors. Rodríguez-Colman et al. examined the metabolic activities of ISCs and Paneth cells. The authors used in vitro models of crypt differentiation and ISC function to identify distinct, yet complementary, metabolic programs in these cells. Paneth cells undergo glycolysis to produce lactate. Lactate is then back converted into pyruvate to fuel mitochondrial oxidative phosphorylation (OXPHOS) in ISCs. This process generates reactive oxygen species (ROS) that in turn activate p38 MAP kinase signaling. Together, these processes promote intestinal crypt differentiation.

Comment on

• Interplay between metabolic identities in the intestinal crypt supports stem cell function.
  Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, Verhoeven-Duif N, Fodde R, Burgering BM. Rodríguez-Colman MJ, et al. Nature. 2017 Mar 16;543(7645):424-427. doi: 10.1038/nature21673. Epub 2017 Mar 8. Nature. 2017. PMID: 28273069

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