Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults - PubMed (original) (raw)

Review

doi: 10.1177/2050640616689525. Epub 2017 Jan 23.

Javier Molina-Infante 2 3, Ángel Arias 2 4, Ulrike von Arnim 5, Albert J Bredenoord 6, Christian Bussmann 7, Jorge Amil Dias 8, Mogens Bove 9, Jesús González-Cervera 2 10, Helen Larsson 9, Stephan Miehlke 11, Alexandra Papadopoulou [ 12](#full-view-affiliation-12 "Division of Pediatric Gastroenterology and Hepatology, Athens Children's Hospital "Agia Sofia", University of Athens, Athens, Greece."), Joaquín Rodríguez-Sánchez 13, Alberto Ravelli 14, Jukka Ronkainen 15, Cecilio Santander 2 16, Alain M Schoepfer 17, Martin A Storr 18, Ingrid Terreehorst 19, Alex Straumann 20, Stephen E Attwood 21

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Review

Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults

Alfredo J Lucendo et al. United European Gastroenterol J. 2017 Apr.

Abstract

Introduction: Eosinophilic esophagitis (EoE) is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. This underlines the importance of optimizing diagnosys and treatment of the condition, especially after the increasing amount of knowledge on EoE recently published. Therefore, the UEG, EAACI ESPGHAN, and EUREOS deemed it necessary to update the current guidelines regarding conceptual and epidemiological aspects, diagnosis, and treatment of EoE.

Methods: General methodology according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used in order to comply with current standards of evidence assessment in formulation of recommendations. An extensive literature search was conducted up to August 2015 and periodically updated. The working group consisted of gastroenterologists, allergists, pediatricians, otolaryngologists, pathologists, and epidemiologists. Systematic evidence-based reviews were performed based upon relevant clinical questions with respect to patient-important outcomes.

Results: The guidelines include updated concept of EoE, evaluated information on disease epidemiology, risk factors, associated conditions, and natural history of EoE in children and adults. Diagnostic conditions and criteria, the yield of diagnostic and disease monitoring procedures, and evidence-based statements and recommendation on the utility of the several treatment options for patients EoE are provided. Recommendations on how to choose and implement treatment and long-term management are provided based on expert opinion and best clinical practice.

Conclusion: Evidence-based recommendations for EoE diagnosis, treatment modalities, and patients' follow up are proposed in the guideline.

Keywords: Eosinophilic esophagitis; consensus development conferences; evidence-based practice; guidelines.

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Figures

Figure 1.

Figure 1.

Therapeutic algorithm proposed for eosinophilic esophagitis in clinical practice.

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References

    1. Attwood SE, Smyrk TC, Demeester TRJJ. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci 1993; 38: 109–116. - PubMed
    1. Straumann A, Spichtin HP, Bernoulli R, et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr 1994; 124: 1419–1429. - PubMed
    1. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342–1363. - PubMed
    1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011; 128: 3–20. - PubMed
    1. Papadopoulou A, Koletzko S, Heuschkel R, et al. Management guidelines of eosinophilic esophagitis in childhood. J Pediatr Gastroenterol Nutr 2014; 58: 107–118. - PubMed

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