STABILIZING SELECTION DETECTED FOR BRISTLE NUMBER IN DROSOPHILA MELANOGASTER - PubMed (original) (raw)
STABILIZING SELECTION DETECTED FOR BRISTLE NUMBER IN DROSOPHILA MELANOGASTER
Aurora García-Dorado et al. Evolution. 1996 Aug.
Abstract
Stabilizing selection, which favors intermediate phenotypes, is frequently invoked as the selective force maintaining a population's status quo. Two main alternative reasons for stabilizing selection on a quantitative trait are possible: (1) intermediate trait values can be favored through the causal effect of the trait on fitness (direct stabilizing selection); or (2) through a pleiotropic, deleterious side effect on fitness of mutants affecting the trait (apparent stabilizing selection). Up to now, these alternatives have never been experimentally disentangled. Here we measure fitness as a function of the number of abdominal bristles within four Drosophila melanogaster lines, one with high, one with low, and two with intermediate average bristle number. The four were inbred nonsegregating lines, so that apparent selection due to pleiotropy is not possible. Individual fitness significantly increased (decreased) with bristles number in the low (high) line. No significant fitness-trait association was detected within each intermediate line. These results reveal substantial direct stabilizing selection on the trait.
Keywords: Causal selection; natural selection; stabilizing selection.
© 1996 The Society for the Study of Evolution.
Similar articles
- Polygenic mutation in Drosophila melanogaster: the causal relationship of bristle number to fitness.
Nuzhdin SV, Fry JD, Mackay TF. Nuzhdin SV, et al. Genetics. 1995 Feb;139(2):861-72. doi: 10.1093/genetics/139.2.861. Genetics. 1995. PMID: 7713437 Free PMC article. - POLYGENIC MUTATION IN DROSOPHILA MELANOGASTER: ESTIMATES FROM DIVERGENCE AMONG INBRED STRAINS.
Mackay TFC, Lyman RF, Jackson MS, Terzian C, Hill WG. Mackay TFC, et al. Evolution. 1992 Apr;46(2):300-316. doi: 10.1111/j.1558-5646.1992.tb02039.x. Evolution. 1992. PMID: 28564027 - Spontaneous mutation for a quantitative trait in Drosophila melanogaster. II. Distribution of mutant effects on the trait and fitness.
López MA, López-Fanjul C. López MA, et al. Genet Res. 1993 Apr;61(2):117-26. doi: 10.1017/s0016672300031220. Genet Res. 1993. PMID: 8319901 - The nature of quantitative genetic variation revisited: lessons from Drosophila bristles.
Mackay TF. Mackay TF. Bioessays. 1996 Feb;18(2):113-21. doi: 10.1002/bies.950180207. Bioessays. 1996. PMID: 8851044 Review.
Cited by
- Drosophila bristles and the nature of quantitative genetic variation.
Mackay TF, Lyman RF. Mackay TF, et al. Philos Trans R Soc Lond B Biol Sci. 2005 Jul 29;360(1459):1513-27. doi: 10.1098/rstb.2005.1672. Philos Trans R Soc Lond B Biol Sci. 2005. PMID: 16108138 Free PMC article. Review. - Prospects for identifying functional variation across the genome.
Macdonald SJ, Long AD. Macdonald SJ, et al. Proc Natl Acad Sci U S A. 2005 May 3;102 Suppl 1(Suppl 1):6614-21. doi: 10.1073/pnas.0501990102. Epub 2005 Apr 25. Proc Natl Acad Sci U S A. 2005. PMID: 15851675 Free PMC article. - Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster.
Macdonald SJ, Long AD. Macdonald SJ, et al. Genetics. 2007 Jun;176(2):1261-81. doi: 10.1534/genetics.106.069641. Epub 2007 Apr 15. Genetics. 2007. PMID: 17435224 Free PMC article. - Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster.
Dworkin I, Palsson A, Gibson G. Dworkin I, et al. Genetics. 2005 Apr;169(4):2115-25. doi: 10.1534/genetics.104.035766. Epub 2005 Jan 31. Genetics. 2005. PMID: 15687273 Free PMC article. - Allelic diversity and its implications for the rate of adaptation.
Caballero A, García-Dorado A. Caballero A, et al. Genetics. 2013 Dec;195(4):1373-84. doi: 10.1534/genetics.113.158410. Epub 2013 Oct 11. Genetics. 2013. PMID: 24121776 Free PMC article.
LinkOut - more resources
Full Text Sources
Molecular Biology Databases