Molecular definitions of autophagy and related processes - PubMed (original) (raw)

Review

. 2017 Jul 3;36(13):1811-1836.

doi: 10.15252/embj.201796697. Epub 2017 Jun 8.

Eric H Baehrecke 3, Andrea Ballabio 4 5 6 7, Patricia Boya 8, José Manuel Bravo-San Pedro 2 9 10 11 12, Francesco Cecconi 13 14 15, Augustine M Choi 16, Charleen T Chu 17, Patrice Codogno 2 18 19 20, Maria Isabel Colombo 21 22, Ana Maria Cuervo 23, Jayanta Debnath 24, Vojo Deretic 25, Ivan Dikic 26 27 28, Eeva-Liisa Eskelinen 29, Gian Maria Fimia [ 30](#full-view-affiliation-30 "National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.") 31, Simone Fulda 32 33 34, David A Gewirtz 35 36, Douglas R Green 37, Malene Hansen 38, J Wade Harper 39, Marja Jäättelä 40, Terje Johansen 41, Gabor Juhasz 42 43, Alec C Kimmelman 44, Claudine Kraft 45, Nicholas T Ktistakis 46, Sharad Kumar 47, Beth Levine 48 49, Carlos Lopez-Otin 50 51, Frank Madeo 52 53, Sascha Martens 45, Jennifer Martinez 54, Alicia Melendez 55 56, Noboru Mizushima 57, Christian Münz 58, Leon O Murphy 59, Josef M Penninger 60, Mauro Piacentini 13 [ 30](#full-view-affiliation-30 "National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy."), Fulvio Reggiori 61, David C Rubinsztein 62, Kevin M Ryan 63, Laura Santambrogio 64, Luca Scorrano 65 66, Anna Katharina Simon 67 68, Hans-Uwe Simon 69, Anne Simonsen 70, Nektarios Tavernarakis 71 72, Sharon A Tooze 73, Tamotsu Yoshimori 74 75, Junying Yuan 39 76, Zhenyu Yue 77, Qing Zhong 48, Guido Kroemer 2 9 10 11 12 78 79

Affiliations

Review

Lorenzo Galluzzi et al. EMBO J. 2017.

Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Keywords: LC3‐associated phagocytosis; chaperone‐mediated autophagy; microautophagy; mitophagy; xenophagy.

© 2017 The Authors.

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Figures

Figure 1

Figure 1. Autophagy substrates

A wide and heterogeneous set of cytoplasmic entities—be they of endogenous/intracellular or exogenous/extracellular origin—can be targeted to lysosomal degradation by non‐selective or selective forms of autophagy.

ER

, endoplasmic reticulum.

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