Clinical viral infections and multiple sclerosis - PubMed (original) (raw)
Clinical viral infections and multiple sclerosis
W A Sibley et al. Lancet. 1985.
Abstract
Over an 8 year period, 170 patients with multiple sclerosis (MS) and 134 healthy controls were assessed at monthly intervals in order to ascertain environmental factors which might be important in producing exacerbation or progression of the illness, and to compare the frequency of common viral infections in the two groups. During cumulative periods designated "at risk" (2 weeks before the onset of infection until 5 weeks afterwards) annual exacerbation rates were almost 3-fold greater than those during periods not at risk. Approximately 9% of infections were temporally related to exacerbations, whereas 27% of exacerbations were related to infections. Frequency of common infections was approximately 20-50% less in MS patients than controls; it was progressively less in those with greater disability. Even in minimally disabled patients with similar potential for infectious contacts, the infection rate was significantly less than in controls, suggesting that MS patients could have superior immune defences against common viruses.
Similar articles
- Influence of infection on exacerbations of multiple sclerosis.
Panitch HS. Panitch HS. Ann Neurol. 1994;36 Suppl(Suppl ):S25-8. doi: 10.1002/ana.410360709. Ann Neurol. 1994. PMID: 8017885 Free PMC article. - Multiple sclerosis in the Orkney and Shetland Islands. IV: Viral antibody titres and viral infections.
Poskanzer DC, Sever JL, Sheridan JL, Prenney LB. Poskanzer DC, et al. J Epidemiol Community Health. 1980 Dec;34(4):258-64. doi: 10.1136/jech.34.4.258. J Epidemiol Community Health. 1980. PMID: 7241024 Free PMC article. - The role of infections in multiple sclerosis.
Marrodan M, Alessandro L, Farez MF, Correale J. Marrodan M, et al. Mult Scler. 2019 Jun;25(7):891-901. doi: 10.1177/1352458518823940. Epub 2019 Jan 14. Mult Scler. 2019. PMID: 30638421 Review. - Clues to the mystery of multiple sclerosis.
Gorelick PB. Gorelick PB. Postgrad Med. 1989 Mar;85(4):125-8, 131-4. doi: 10.1080/00325481.1989.11700620. Postgrad Med. 1989. PMID: 2648350 Review. - Clinical infections and multiple sclerosis: contribution from analytical epidemiology.
Casetta I, Granieri E. Casetta I, et al. J Neurovirol. 2000 May;6 Suppl 2:S147-51. J Neurovirol. 2000. PMID: 10871803 Review.
Cited by
- Systemic inflammation associates with and precedes cord atrophy in progressive multiple sclerosis.
Stuart CM, Varatharaj A, Zou Y, Darekar A, Domjan J, Gandini Wheeler-Kingshott CAM, Perry VH, Galea I. Stuart CM, et al. Brain Commun. 2024 Apr 20;6(3):fcae143. doi: 10.1093/braincomms/fcae143. eCollection 2024. Brain Commun. 2024. PMID: 38712323 Free PMC article. - Vaccination frequency in people newly diagnosed with multiple sclerosis.
Darvishi S, Donnachie E, Gasperi C, Hapfelmeier A, Hemmer B. Darvishi S, et al. Mult Scler. 2023 Dec;29(14):1831-1840. doi: 10.1177/13524585231199084. Epub 2023 Oct 13. Mult Scler. 2023. PMID: 37830337 Free PMC article. - The association of upper respiratory infections with neuro-radiological course and attack rate of multiple sclerosis: Results from a large prospective cohort.
Ghasemi M, Farazandeh D, Amini B, Sedaghat M, Najafi A, Khayatzadeh Kakhki S, Torabi P, Jafarimehrabady N, Bitaraf A, Shariati H, Gholampour G, Kazemi S, Naser Moghadasi A, Vajihinejad M. Ghasemi M, et al. Mult Scler J Exp Transl Clin. 2023 Sep 25;9(3):20552173231196992. doi: 10.1177/20552173231196992. eCollection 2023 Jul-Sep. Mult Scler J Exp Transl Clin. 2023. PMID: 37767104 Free PMC article. - Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models.
Reder AT. Reder AT. J Clin Invest. 2023 May 1;133(9):e169643. doi: 10.1172/JCI169643. J Clin Invest. 2023. PMID: 37115699 Free PMC article. - Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease.
Corbali O, Chitnis T. Corbali O, et al. Front Neurol. 2023 Feb 28;14:1137998. doi: 10.3389/fneur.2023.1137998. eCollection 2023. Front Neurol. 2023. PMID: 36925938 Free PMC article. Review.
References
- Bamford Cr, Sibley Wa, Thies C., Laguna Jf, Smith Ms, Clark K. Trauma as an etiologic and aggravating factor in multiple sclerosis. Neurology (NY) 1981;31:1229–1234. - PubMed
- Bamford Cr, Sibley Wa, Laguna Jf. Anesthesia in Multiple sclerosis. Can J Neurol Sci. 1978;5:41–44. - PubMed
- Bamford Cr, Sibley Wa, Laguna Jf. Swine influenza vaccination in patients with multiple sclerosis. Arch Neurol. 1978;35:242–243. - PubMed
- Bamford Cr, Sibley Wa, Thies C. Seasonal variation of multiple sclerosis exacerbations in Arizona. Neurology (NY) 1983;33:697–701. - PubMed
- Schumacher Ga, Beebe G., Kibler Rf. Problems of experimental trials of therapy in multiple sclerosis: Report by the panel on evaluation of experimental trials of therapy in multiple sclerosis. Ann NY Acad Sci. 1965;122:552–568. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical