Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape - PubMed (original) (raw)

Review

. 2017 Aug;38(8):577-593.

doi: 10.1016/j.it.2017.05.006. Epub 2017 Jun 10.

Affiliations

• PMID: 28610825
• DOI: 10.1016/j.it.2017.05.006

Review

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

Abhishek D Garg et al. Trends Immunol. 2017 Aug.

Abstract

Cancer immunotherapy is experiencing a renaissance spearheaded by immune checkpoint inhibitors (ICIs). This has spurred interest in 'upgrading' existing immunotherapies that previously experienced only sporadic success, such as dendritic cells (DCs) vaccines. In this review, we discuss the major molecular, immunological, and clinical determinants of existing first- and second-generation DC vaccines. We also outline the future trends for next-generation DC vaccines and describe their major hallmarks and prerequisites necessary for high anticancer efficacy. In addition, using existing data we compare DC vaccines with ICIs targeting CTLA4, PD1, and PD-L1, and argue that in various contexts next-generation DC vaccines are ready to meet some challenges currently confronting ICIs, thereby raising the need to integrate DC vaccines in future combinatorial immunotherapy regimens.

Copyright © 2017 Elsevier Ltd. All rights reserved.

PubMed Disclaimer

Similar articles

• Current status and future perspectives of dendritic cell-based cancer immunotherapy.
  H Yi D, Appel S. H Yi D, et al. Scand J Immunol. 2013 Aug;78(2):167-71. doi: 10.1111/sji.12060. Scand J Immunol. 2013. PMID: 23672402 Review.
• Dendritic cells and cancer immunotherapy.
  Radford KJ, Tullett KM, Lahoud MH. Radford KJ, et al. Curr Opin Immunol. 2014 Apr;27:26-32. doi: 10.1016/j.coi.2014.01.005. Epub 2014 Feb 8. Curr Opin Immunol. 2014. PMID: 24513968 Review.
• Dendritic cell-based immunotherapy.
  Osada T, Clay TM, Woo CY, Morse MA, Lyerly HK. Osada T, et al. Int Rev Immunol. 2006 Sep-Dec;25(5-6):377-413. doi: 10.1080/08830180600992456. Int Rev Immunol. 2006. PMID: 17169781 Review.
• Next-generation cancer vaccines and emerging immunotherapy combinations.
  Brandenburg A, Heine A, Brossart P. Brandenburg A, et al. Trends Cancer. 2024 Aug;10(8):749-769. doi: 10.1016/j.trecan.2024.06.003. Epub 2024 Jul 23. Trends Cancer. 2024. PMID: 39048489 Review.
• Enhancing Dendritic Cell Cancer Vaccination: The Synergy of Immune Checkpoint Inhibitors in Combined Therapies.
  Zanotta S, Galati D, De Filippi R, Pinto A. Zanotta S, et al. Int J Mol Sci. 2024 Jul 9;25(14):7509. doi: 10.3390/ijms25147509. Int J Mol Sci. 2024. PMID: 39062753 Free PMC article. Review.

Cited by

• Trial watch: anticancer vaccination with dendritic cells.
  Borges F, Laureano RS, Vanmeerbeek I, Sprooten J, Demeulenaere O, Govaerts J, Kinget L, Saraswat S, Beuselinck B, De Vleeschouwer S, Clement P, De Smet F, Sorg RV, Datsi A, Vigneron N, Naulaerts S, Garg AD. Borges F, et al. Oncoimmunology. 2024 Oct 9;13(1):2412876. doi: 10.1080/2162402X.2024.2412876. eCollection 2024. Oncoimmunology. 2024. PMID: 39398476 Free PMC article. Review.
• Prognosis of colorectal cancer, prognostic index of immunogenic cell death associated genes in response to immunotherapy, and potential therapeutic effects of ferroptosis inducers.
  Lei M, Xiao M, Long Z, Lin T, Ding R, Quan Q. Lei M, et al. Front Immunol. 2024 Sep 20;15:1458270. doi: 10.3389/fimmu.2024.1458270. eCollection 2024. Front Immunol. 2024. PMID: 39372411 Free PMC article.
• The current role of dendritic cells in the progression and treatment of colorectal cancer.
  Zhang Y, Ji S, Miao G, Du S, Wang H, Yang X, Li A, Lu Y, Wang X, Zhao X. Zhang Y, et al. Cancer Biol Med. 2024 Aug 22;21(9):769-83. doi: 10.20892/j.issn.2095-3941.2024.0188. Cancer Biol Med. 2024. PMID: 39177125 Free PMC article. Review.
• Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform.
  Luo J, Mo F, Zhang Z, Hong W, Lan T, Cheng Y, Fang C, Bi Z, Qin F, Yang J, Zhang Z, Li X, Que H, Wang J, Chen S, Wu Y, Yang L, Li J, Wang W, Chen C, Wei X. Luo J, et al. Cell Mol Immunol. 2024 Nov;21(11):1251-1265. doi: 10.1038/s41423-024-01203-4. Epub 2024 Aug 20. Cell Mol Immunol. 2024. PMID: 39164536 Free PMC article.
• An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer.
  Lin Y, Chen X, Wang K, Liang L, Zhang H. Lin Y, et al. Vaccines (Basel). 2024 Jun 29;12(7):727. doi: 10.3390/vaccines12070727. Vaccines (Basel). 2024. PMID: 39066365 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program