IL-25 in allergic inflammation - PubMed (original) (raw)

Review

. 2017 Jul;278(1):185-191.

doi: 10.1111/imr.12558.

Affiliations

Review

IL-25 in allergic inflammation

Miao Xu et al. Immunol Rev. 2017 Jul.

Abstract

IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions. Our knowledge on IL-25 will pave the pathway for targeting this cytokine in inflammatory diseases.

Keywords: IL-25; IL-25-mediated diseases; allergic diseases; cell source; cell target; cytokines.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources