Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? - PubMed (original) (raw)

Review

Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?

Pedro Henrique França Gois et al. Nutrients. 2017.

Abstract

Vitamin D (VD) is a fat-soluble steroid essential for life in higher animals. It is technically a pro-hormone present in few food types and produced endogenously in the skin by a photochemical reaction. In recent decades, several studies have suggested that VD contributes to diverse processes extending far beyond mineral homeostasis. The machinery for VD production and its receptor have been reported in multiple tissues, where they have a pivotal role in modulating the immune system. Similarly, vitamin D deficiency (VDD) has been in the spotlight as a major global public healthcare burden. VDD is highly prevalent throughout different regions of the world, including tropical and subtropical countries. Moreover, VDD may affect host immunity leading to an increased incidence and severity of several infectious diseases. In this review, we discuss new insights on VD physiology as well as the relationship between VD status and various infectious diseases such as tuberculosis, respiratory tract infections, human immunodeficiency virus, fungal infections and sepsis. Finally, we critically review the latest evidence on VD monitoring and supplementation in the setting of infectious diseases.

Keywords: HIV/AIDS; fungal infections; infectious diseases; oxidative stress; sepsis; tuberculosis; vitamin D; vitamin D deficiency.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Vitamin D activation and metabolism.

Figure 2

Prevalence of vitamin D deficiency/insufficiency in general population worldwide [7,8,9].

Figure 3

Vitamin D up-regulates the innate defense against Mycobacterium tuberculosis (a) M. tuberculosis binds to the TLR1-TLR2 heterodimer in monocytes leading to the transcriptional induction of VDR and 25(OH)-VD-1-α-hydroxylase; (b) Activation of IL-1 and induction of NFκB by TLR1-TLR2. Phagocytosis of M. tuberculosis as well as the binding of 1,25(OH)2-VD to the VDR activate the intracellular pathogen-recognition receptor NOD2 increasing NFκB activity. In concert, NFκB enhances the expression of cathelicidin and beta-defensin 4A. This ultimately contributes to bacterial killing. Adapted from Hewison, M [15].

Figure 3

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Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? - PubMed (original) (raw)