Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium - PubMed (original) (raw)

. 2017 Nov 15;141(10):1950-1962.

doi: 10.1002/ijc.30891. Epub 2017 Aug 8.

Claudio Pelucchi 1 3, Paola Bertuccio 3, Keitaro Matsuo 4, Zuo-Feng Zhang 5, Hidemi Ito 6, Jinfu Hu 7, Kenneth C Johnson 8, Domenico Palli 9, Monica Ferraroni 3, Guo-Pei Yu 10, Joshua Muscat 11, Nuno Lunet 12 13, Bárbara Peleteiro 12 13, Weimin Ye 14, Huan Song 14, David Zaridze 15, Dmitry Maximovitch 15, Marcela Guevara 16 17, Tania Fernández-Villa 18, Jesus Vioque 17 19, Eva M Navarrete-Muñoz 17 19, Alicja Wolk 20, Nicola Orsini 20, Andrea Bellavia 20, Niclas Håkansson 20, Lina Mu 21, Roberto Persiani [ 22](#full-view-affiliation-22 "Department of Surgical Sciences, Division of General Surgery, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "Agostino Gemelli", Rome, Italy."), Robert C Kurtz 23, Areti Lagiou 24, Pagona Lagiou 25 26, Carlotta Galeone 3, Rossella Bonzi 3, Paolo Boffetta 27, Stefania Boccia [ 28](#full-view-affiliation-28 "Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "Agostino Gemelli,", Rome, Italy."), Eva Negri 2, Carlo La Vecchia 3

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Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium

Matteo Rota et al. Int J Cancer. 2017.

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Abstract

An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the "Stomach cancer Pooling (StoP) Project," a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects meta-regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08-1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29-1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35-2.58) as compared with current smokers (OR 1.14, 95% CI 0.93-1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11-2.34) than in non-cardia (OR 1.28, 95% CI 1.13-1.45) gastric cancers, and in intestinal-type (OR 1.54, 95% CI 1.20-1.97) than in diffuse-type (OR 1.29, 95% CI 1.05-1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16-2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95-3.01). Our collaborative pooled-analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.

Keywords: alcohol drinking; case-control studies; gastric cancer; pooled analysis; risk factors.

© 2017 UICC.

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