Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue - PubMed (original) (raw)
doi: 10.1159/000479268. Epub 2017 Jul 18.
Dandan Zhao 1, Na Yu 1, Xin Fang 2, Qianqian Mu 1, Yue Ma 1, Fangfang Mo 1, Rui Wu 3, Rufeng Ma 1, Lili Wang 1, Ruyuan Zhu 1, Haixia Liu 1, Dongwei Zhang 1, Sihua Gao 1
Affiliations
- PMID: 28719892
- DOI: 10.1159/000479268
Free article
Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue
Jiacheng Zuo et al. Cell Physiol Biochem. 2017.
Free article
Abstract
Background/aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) has been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed to investigate the potential anti-obesity effects of CA on mice fed a high-fat diet (HFD) and to explore the possible mechanisms involved.
Methods: Male C57BL/6J mice fed an HFD for 12 weeks were supplemented with CA (40 mg/kg/day) via gavage for an additional 8 weeks. Mice fed a standard diet were used as normal controls.
Results: The results revealed that CA treatment decreased body weight, fat mass, food intake, and serum lipid, free fatty acid and leptin levels. CA administration also improved insulin sensitivity in HFD-induced obese mice. Additionally, CA inhibited the hypertrophy of adipose tissue and induced browning of white adipose tissue. Uncoupling protein 1 (UCP1) was expressed in white adipose tissue after the oral administration of CA. Furthermore, CA enhanced the expression of the peroxisome proliferator-activated receptor γ (PPARγ), PR domain-containing 16 (PRDM16) and PPARγ coactivator 1α (PGC-1α) proteins in both brown and white adipose tissues.
Conclusions: The results suggest that CA exhibits therapeutic potency against obesity by inducing the browning of white adipose tissue in HFD-fed mice.
Keywords: Adipose tissue browning; Anti-obesity; Cinnamaldehyde; Fat mass; Mice.
© 2017 The Author(s). Published by S. Karger AG, Basel.
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