The Urinary Tract Microbiome in Health and Disease - PubMed (original) (raw)
Review
The Urinary Tract Microbiome in Health and Disease
Isabel M Aragón et al. Eur Urol Focus. 2018 Jan.
Abstract
Context: The urinary tract, previously considered a sterile body niche, has emerged as the host of an array of bacteria in healthy individuals, revolutionizing the urology research field.
Objective: To review the literature on microbiome implications in the urinary tract and the usefulness of probiotics/prebiotics and diet as treatment for urologic disorders.
Evidence acquisition: A systematic review was conducted using PubMed and Medline from inception until July 2016. The initial search identified 1419 studies and 89 were included in this systematic review.
Evidence synthesis: Specific bacterial communities have been found in the healthy urinary tract. Changes in this microbiome have been observed in certain urologic disorders such as urinary incontinence, urologic cancers, interstitial cystitis, neurogenic bladder dysfunction, sexually transmitted infections, and chronic prostatitis/chronic pelvic pain syndrome. The role of probiotics, prebiotics, and diet as treatment or preventive agents for urologic disorders requires further investigation.
Conclusions: There is a microbiome associated with the healthy urinary tract that can change in urologic disorders. This represents a propitious context to identify new diagnostic, prognostic, and predictive microbiome-based biomarkers that could be used in clinical urology practice. In addition, probiotics, prebiotics, and diet modifications appear to represent an opportunity to regulate the urinary microbiome.
Patient summary: We review the urinary microbiome of healthy individuals and its changes in relation to urinary disorders. The question to resolve is how we can modulate the microbiome to improve urinary tract health.
Keywords: 16S rRNA sequencing; Prebiotics; Probiotics; Urinary microbiome; Urinary tract; Urine culture; Urologic disorders.
Copyright © 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Similar articles
- Urobiome: An outlook on the metagenome of urological diseases.
Shoemaker R, Kim J. Shoemaker R, et al. Investig Clin Urol. 2021 Nov;62(6):611-622. doi: 10.4111/icu.20210312. Investig Clin Urol. 2021. PMID: 34729961 Free PMC article. Review. - The Urinary Tract Microbiome: The Answer to All Our Open Questions?
Magistro G, Stief CG. Magistro G, et al. Eur Urol Focus. 2019 Jan;5(1):36-38. doi: 10.1016/j.euf.2018.06.011. Epub 2018 Jul 2. Eur Urol Focus. 2019. PMID: 30042043 Review. - Clinical implications of the microbiome in urinary tract diseases.
Hiergeist A, Gessner A. Hiergeist A, et al. Curr Opin Urol. 2017 Mar;27(2):93-98. doi: 10.1097/MOU.0000000000000367. Curr Opin Urol. 2017. PMID: 27898455 Review. - The Role of Urinary Microbiota in Lower Urinary Tract Dysfunction: A Systematic Review.
Antunes-Lopes T, Vale L, Coelho AM, Silva C, Rieken M, Geavlete B, Rashid T, Rahnama'i SM, Cornu JN, Marcelissen T; EAU Young Academic Urologists (YAU) Functional Urology Working Group. Antunes-Lopes T, et al. Eur Urol Focus. 2020 Mar 15;6(2):361-369. doi: 10.1016/j.euf.2018.09.011. Epub 2018 Sep 28. Eur Urol Focus. 2020. PMID: 30270128 - The female urinary microbiome: a comparison of women with and without urgency urinary incontinence.
Pearce MM, Hilt EE, Rosenfeld AB, Zilliox MJ, Thomas-White K, Fok C, Kliethermes S, Schreckenberger PC, Brubaker L, Gai X, Wolfe AJ. Pearce MM, et al. mBio. 2014 Jul 8;5(4):e01283-14. doi: 10.1128/mBio.01283-14. mBio. 2014. PMID: 25006228 Free PMC article.
Cited by
- Microbiome and Prostate Cancer: Emerging Diagnostic and Therapeutic Opportunities.
Kim SJ, Park M, Choi A, Yoo S. Kim SJ, et al. Pharmaceuticals (Basel). 2024 Jan 13;17(1):112. doi: 10.3390/ph17010112. Pharmaceuticals (Basel). 2024. PMID: 38256945 Free PMC article. Review. - Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.
Petrelli F, Ghidini M, Ghidini A, Perego G, Cabiddu M, Khakoo S, Oggionni E, Abeni C, Hahne JC, Tomasello G, Zaniboni A. Petrelli F, et al. Cancers (Basel). 2019 Aug 14;11(8):1174. doi: 10.3390/cancers11081174. Cancers (Basel). 2019. PMID: 31416208 Free PMC article. - The Urobiome and Its Role in Overactive Bladder.
Bae S, Chung H. Bae S, et al. Int Neurourol J. 2022 Sep;26(3):190-200. doi: 10.5213/inj.2244016.008. Epub 2022 Apr 22. Int Neurourol J. 2022. PMID: 35468617 Free PMC article. - Urobiome: An outlook on the metagenome of urological diseases.
Shoemaker R, Kim J. Shoemaker R, et al. Investig Clin Urol. 2021 Nov;62(6):611-622. doi: 10.4111/icu.20210312. Investig Clin Urol. 2021. PMID: 34729961 Free PMC article. Review. - Urinary tract infections (UTIs) or genital tract infections (GTIs)? It's the diagnostics that count.
Behzadi P, Behzadi E, Pawlak-Adamska EA. Behzadi P, et al. GMS Hyg Infect Control. 2019 Feb 18;14:Doc14. doi: 10.3205/dgkh000320. eCollection 2019. GMS Hyg Infect Control. 2019. PMID: 30993060 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical