Neuroprotective Effects of Stem Cells in Ischemic Stroke - PubMed (original) (raw)

Review

Neuroprotective Effects of Stem Cells in Ischemic Stroke

Weilin Xu et al. Stem Cells Int. 2017.

Abstract

Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.

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References

1. 1. Sun N., Keep R. F., Hua Y., Xi G. Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets. Translational Stroke Research. 2016;7(5):420–438. doi: 10.1007/s12975-016-0477-3. - DOI - PMC - PubMed
2. 1. Xia Y., Cai W., Thomson A. W., Hu X. Regulatory T cell therapy for ischemic stroke: how far from clinical translation? Translational Stroke Research. 2016;7(5):415–419. doi: 10.1007/s12975-016-0476-4. - DOI - PMC - PubMed
3. 1. Ahnstedt H., Sweet J., Cruden P., Bishop N., Cipolla M. J. Effects of early post-ischemic reperfusion and tPA on cerebrovascular function and nitrosative stress in female rats. Translational Stroke Research. 2016;7(3):228–238. doi: 10.1007/s12975-016-0468-4. - DOI - PMC - PubMed
4. 1. Zuo W., Zhang W., Chen N. H. Sexual dimorphism in cerebral ischemia injury. European Journal of Pharmacology. 2013;711:73–79. doi: 10.1016/j.ejphar.2013.04.024. - DOI - PubMed
5. 1. Yi B. R., Kim S. U., Choi K. C. Development and application of neural stem cells for treating various human neurological diseases in animal models. Laboratory Animal Research. 2013;29(3):131–137. doi: 10.5625/lar.2013.29.3.131. - DOI - PMC - PubMed

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