Ethnic Differences in the Risk Factors and Severity of Coronary Artery Disease: a Patient-Based Study in Iran - PubMed (original) (raw)

Ethnic Differences in the Risk Factors and Severity of Coronary Artery Disease: a Patient-Based Study in Iran

Seyed Hesameddin Abbasi et al. J Racial Ethn Health Disparities. 2018 Jun.

Abstract

Background: Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups.

Methods: In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved. The Gensini score (an indicator of CAD severity) was calculated for all, and the risk factors and severity of CAD were compared between the ethnical groups, using adjusted standardized residuals, Kruskal-Wallis test, and multivariable regression analysis.

Results: The mean age of the participants (14,131 [70.1%] men and 6034 [29.9%] women) was 60.7 ± 10.8 years. The Fars (8.7%) and Gilak (8.6%) ethnic groups had the highest prevalence of ≥4 simultaneous risk factors. The mean Gensini score was the highest for the Gilaks (77.1 ± 55.9) and the lowest among the Lors (67.5 ± 52.8). The multivariable regression analysis showed that the Gilaks had the worst severity (β 0.056, 95% CI 0.009 to 0.102; P = 0.018), followed by the Torks (β 0.032, 95% CI 0.005 to 0.059; P = 0.020). Meanwhile, the Lors showed the lowest severity (β -0.087, 95% CI -0.146 to -0.027; P = 0.004).

Conclusions: This study found that there was heterogeneity in CAD severity and a diverse distribution in its well-known traditional risk factors among major Iranian ethnic groups.

Keywords: Coronary artery disease; Ethnicity; Health status disparities; Iran.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1

Fig. 1

Distribution of different risk factors among ethnicities

References

    1. Abbasi SH, De Leon AP, Kassaian S, Karimi A, Sundin O, Soares J, Macassa G. Gender differences in the risk of coronary artery disease in Iran. Iran J Public Health. 2012;41:36–47. -PMC -PubMed
    1. Francis DK, Bennett NR, Ferguson TS, Hennis AJ, Wilks RJ, US Caribbean Alliance for Health Disparities Research Group et al. Disparities in cardiovascular disease among Caribbean populations: a systematic literature review. BMC Public Health. 2015;15:828. doi: 10.1186/s12889-015-2166-7. -DOI -PMC -PubMed
    1. Dalton AR, Bottle A, Soljak M, Majeed A, Millett C. Ethnic group differences in cardiovascular risk assessment scores: national cross-sectional study. Ethn Health. 2014;19:367–384. doi: 10.1080/13557858.2013.797568. -DOI -PubMed
    1. Kurian AK, Cardarelli KM. Racial and ethnic differences in cardiovascular disease risk factors: a systematic review. Ethn Dis. 2007;17:143–152. -PubMed
    1. Budoff MJ, Nasir K, Mao S, Tseng PH, Chau A, Liu ST, Flores F, Blumenthal RS. Ethnic differences of the presence and severity of coronary atherosclerosis. Atherosclerosis. 2006;187:343–350. doi: 10.1016/j.atherosclerosis.2005.09.013. -DOI -PubMed

Publication types

MeSH terms

LinkOut - more resources