Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma - PubMed (original) (raw)

Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma

Yunliang Shi et al. Parasitol Res. 2017 Oct.

Abstract

To evaluate the contributions of Clonorchis sinensis and hepatitis B virus to the development of cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), C. sinensis and hepatitis B virus infections in 20 clinical liver cancer cases from a C. sinensis- and hepatitis B virus-epidemic region were detected. Eight cases of ICC, 11 cases of HCC and one mixed ICC and HCC case were verified by CT, pathological section and (or) observations during surgery. The C. sinensis infection was detected by stool microscopy and ELISA, and the worms and eggs found during surgery and in pathological sections also allowed for diagnoses. Hepatitis B virus infections were detected by ELISA. In the 20 cases, 18 patients were diagnosed with C. sinensis infections. Eight of the 20 patients were infected with the hepatitis B virus, and seven were co-infected with C. sinensis. In the eight ICC patients, seven were diagnosed with C. sinensis infection, and two had mixed infections with the hepatitis B virus. In the 11 HCC patients, 10 were diagnosed with C. sinensis, four had mixed infections with the hepatitis B virus, and only one HCC patient presented a single infection by the hepatitis B virus. These clinical observations revealed that C. sinensis infection and C. sinensis co-infection with the hepatitis B virus are important factors in ICC and HCC.

Keywords: Clonorchis sinensis; Hepatitis B virus; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma.

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Conflict of interest statement

Institutional review board statement

Institutional Review Board (IRB) approval by the Guangxi Institutional Review Board (GXIRB) (IRB00001594).

Conflict of interest

The authors declare that they have no conflict of interest.

Figures

Fig. 1

Fig. 1

CT diagnosis and biopsy of cholangiocarcinoma and hepatocellular carcinoma. a CT diagnosis of hepatocellular carcinoma. b CT diagnosis of intrahepatic cholangiocarcinoma. c Liver biopsy of hepatocellular carcinoma (magnification ×400). d Liver biopsy of cholangiocarcinoma (magnification ×400)

Fig. 2

Fig. 2

Pathologic observations of cholangiocarcinoma and hepatocellular carcinoma infected with Clonorchis sinensis. a Flukes were found in the duct during surgery. b Flukes were found in the bile during surgery. c Flukes were found in sites of liver damage. d Intrahepatic cholangiocarcinoma liver with Clonorchis sinensis infection. e and f Hepatocellular carcinoma in the liver with Clonorchis sinensis infection

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