Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone - PubMed (original) (raw)
. 2017 Aug 24;170(5):860-874.e19.
doi: 10.1016/j.cell.2017.07.022. Epub 2017 Aug 10.
Affiliations
- PMID: 28803730
- DOI: 10.1016/j.cell.2017.07.022
Free article
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone
Miriam R Berry et al. Cell. 2017.
Free article
Abstract
Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that prevent the ascent of bladder microbes. Here, we show that the regional hypersalinity, required for the kidney's urine-concentrating function, instructs epithelial cells to produce chemokines that localize monocyte-derived mononuclear phagocytes (MNPs) to the medulla. This hypersaline environment also increases the intrinsic bactericidal and neutrophil chemotactic activities of MNPs to generate a zone of defense. Because MNP positioning and function are dynamically regulated by the renal salt gradient, we find that patients with urinary concentrating defects are susceptible to kidney infection. Our work reveals a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Keywords: CCL2; NAFT5; diabetes insipidus; kidney; macrophage; monocyte; salt; sodium; urinary tract infection; uropathogenic E. coli.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment in
- Immunology: The renal sodium gradient in antimicrobial defence.
Allison SJ. Allison SJ. Nat Rev Nephrol. 2017 Oct;13(10):595. doi: 10.1038/nrneph.2017.124. Epub 2017 Aug 30. Nat Rev Nephrol. 2017. PMID: 28852210 No abstract available. - A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response.
Wyatt CM, Crowley SD. Wyatt CM, et al. Kidney Int. 2017 Dec;92(6):1308-1311. doi: 10.1016/j.kint.2017.10.005. Kidney Int. 2017. PMID: 29153132 - Re: Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Atala A. Atala A. J Urol. 2018 May;199(5):1116. doi: 10.1016/j.juro.2018.02.016. Epub 2018 Feb 17. J Urol. 2018. PMID: 29677907 No abstract available.
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