A randomized synbiotic trial to prevent sepsis among infants in rural India - PubMed (original) (raw)
Randomized Controlled Trial
. 2017 Aug 24;548(7668):407-412.
doi: 10.1038/nature23480. Epub 2017 Aug 16.
Sailajanandan Parida 3, Nimai C Nanda 4, Radhanath Satpathy 5, Lingaraj Pradhan 6, Dinesh S Chandel 7, Lorena Baccaglini 1, Arjit Mohapatra 5, Subhranshu S Mohapatra 5, Pravas R Misra 5, Rama Chaudhry 8, Hegang H Chen 9, Judith A Johnson 10, J Glenn Morris 10, Nigel Paneth 11, Ira H Gewolb 12
Affiliations
- PMID: 28813414
- DOI: 10.1038/nature23480
Randomized Controlled Trial
A randomized synbiotic trial to prevent sepsis among infants in rural India
Pinaki Panigrahi et al. Nature. 2017.
Erratum in
- Corrigendum: A randomized synbiotic trial to prevent sepsis among infants in rural India.
Panigrahi P, Parida S, Nanda NC, Satpathy R, Pradhan L, Chandel DS, Baccaglini L, Mohapatra A, Mohapatra SS, Misra PR, Chaudhry R, Chen HH, Johnson JA, Morris JG, Paneth N, Gewolb IH. Panigrahi P, et al. Nature. 2018 Jan 11;553(7687):238. doi: 10.1038/nature25006. Epub 2017 Nov 29. Nature. 2018. PMID: 29186118
Abstract
Sepsis in early infancy results in one million annual deaths worldwide, most of them in developing countries. No efficient means of prevention is currently available. Here we report on a randomized, double-blind, placebo-controlled trial of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in rural Indian newborns. We enrolled 4,556 infants that were at least 2,000 g at birth, at least 35 weeks of gestation, and with no signs of sepsis or other morbidity, and monitored them for 60 days. We show a significant reduction in the primary outcome (combination of sepsis and death) in the treatment arm (risk ratio 0.60, 95% confidence interval 0.48-0.74), with few deaths (4 placebo, 6 synbiotic). Significant reductions were also observed for culture-positive and culture-negative sepsis and lower respiratory tract infections. These findings suggest that a large proportion of neonatal sepsis in developing countries could be effectively prevented using a synbiotic containing L. plantarum ATCC-202195.
Comment in
- Global health: Probiotic prevents infections in newborns.
Tancredi DJ. Tancredi DJ. Nature. 2017 Aug 24;548(7668):404-405. doi: 10.1038/nature23540. Epub 2017 Aug 16. Nature. 2017. PMID: 28813407 No abstract available.
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