Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D - PubMed (original) (raw)

Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D

M Ono et al. J Virol. 1987 Jun.

Abstract

Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.

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References

1. 1. Jpn J Exp Med. 1978 Feb;48(1):61-8 - PubMed
2. 1. EMBO J. 1986 Sep;5(9):2237-40 - PubMed
3. 1. Cell. 1980 Sep;21(2):465-73 - PubMed
4. 1. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 - PubMed
5. 1. Nucleic Acids Res. 1982 May 11;10(9):2865-78 - PubMed

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